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Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype.

期刊: Circulation research 日期: 2026-05-08 PMID: 41983287 浏览: 49
作者: Perry R Noah, Lenert Graham, Benavente Ernest Diez, Bölük Aydin, Hernandez Rebecca, Ma Lijiang, Barbera Nicolas, Watts Kelsey, Mendoza Victor D, Örd Tiit, Taipale Mari, Sachs Nadja, Pauli Jessica, Mokry Michal, de Kleijn Dominique P V, de Winther Menno P J, Mayr Manuel, Maegdefessel Lars, Reue Karen, Kaikkonen Minna U, Björkegren Johan L M, den Ruijter Hester M, Civelek Mete
Noah, P.R., Graham, L., Diez, B.E., Aydin, B., Rebecca, H., Lijiang, M., Nicolas, B., Kelsey, W., D, M.V., Tiit, Ö., Mari, T., Nadja, S., Jessica, P., Michal, M., V, d.K.D.P., J, d.W.M.P., Manuel, M., Lars, M., Karen, R., . . . Mete, C. (2026). Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype.. Circulation research.
Noah PR, Graham L, Diez BE, Aydin B, Rebecca H, Lijiang M, et al. Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype.. Circulation research. 2026; PMID: 41983287
Noah PR, Graham L, Diez BE, et al. Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype.[J]. Circulation research. 2026.
@article{noah2026,
  author = {Perry R Noah and Lenert Graham and Benavente Ernest Diez and Bölük Aydin and Hernandez Rebecca and Ma Lijiang and Barbera Nicolas and Watts Kelsey and Mendoza Victor D and Örd Tiit and Taipale Mari and Sachs Nadja and Pauli Jessica and Mokry Michal and de Kleijn Dominique P V and de Winther Menno P J and Mayr Manuel and Maegdefessel Lars and Reue Karen and Kaikkonen Minna U and Björkegren Johan L M and den Ruijter Hester M and Civelek Mete},
  title = {Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype.},
  journal = {Circulation research},
  year = {2026},
  note = {PMID: 41983287},
}
TY  - JOUR
AU  - Perry R Noah
AU  - Lenert Graham
AU  - Benavente Ernest Diez
AU  - Bölük Aydin
AU  - Hernandez Rebecca
AU  - Ma Lijiang
AU  - Barbera Nicolas
AU  - Watts Kelsey
AU  - Mendoza Victor D
AU  - Örd Tiit
AU  - Taipale Mari
AU  - Sachs Nadja
AU  - Pauli Jessica
AU  - Mokry Michal
AU  - de Kleijn Dominique P V
AU  - de Winther Menno P J
AU  - Mayr Manuel
AU  - Maegdefessel Lars
AU  - Reue Karen
AU  - Kaikkonen Minna U
AU  - Björkegren Johan L M
AU  - den Ruijter Hester M
AU  - Civelek Mete
TI  - Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype.
T2  - Circulation research
PY  - 2026
AN  - PMID:41983287
ER  - 

摘要

Atherosclerosis, an inflammatory driver of coronary artery disease, manifests as unstable atheromatous plaques and stable fibrous plaques. Although atheromatous plaques have been extensively studied, fibrous plaques, particularly in women aged <50 years, where erosion contributes significantly to coronary thrombosis, remain less understood. The molecular mechanisms underlying sex differences in plaque biology, including vascular smooth muscle cell contributions, are incompletely defined.

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