The triglyceride-glucose-waist-to-height ratio is the strongest predictor of reduced kidney function in elderly hypertensive patients.
J, L., S, X., Y, Z., D, C., C, L., G, W., & X, L. (2026). The triglyceride-glucose-waist-to-height ratio is the strongest predictor of reduced kidney function in elderly hypertensive patients.. Frontiers in endocrinology. https://doi.org/10.3389/fendo.2026.1789763
J L, S X, Y Z, D C, C L, G W, et al. The triglyceride-glucose-waist-to-height ratio is the strongest predictor of reduced kidney function in elderly hypertensive patients.. Frontiers in endocrinology. 2026; doi: 10.3389/fendo.2026.1789763
J L, S X, Y Z, et al. The triglyceride-glucose-waist-to-height ratio is the strongest predictor of reduced kidney function in elderly hypertensive patients.[J]. Frontiers in endocrinology. 2026. DOI: 10.3389/fendo.2026.1789763.
@article{j2026,
author = {Ling J and Xie S and Zhang Y and Chen D and Lü C and Wang G and Li X},
title = {The triglyceride-glucose-waist-to-height ratio is the strongest predictor of reduced kidney function in elderly hypertensive patients.},
journal = {Frontiers in endocrinology},
year = {2026},
doi = {10.3389/fendo.2026.1789763},
note = {PMID: 42375333},
}
TY - JOUR AU - Ling J AU - Xie S AU - Zhang Y AU - Chen D AU - Lü C AU - Wang G AU - Li X TI - The triglyceride-glucose-waist-to-height ratio is the strongest predictor of reduced kidney function in elderly hypertensive patients. T2 - Frontiers in endocrinology PY - 2026 DO - 10.3389/fendo.2026.1789763 AN - PMID:42375333 ER -
BACKGROUND: The triglyceride-glucose index (TyG) and its derivatives, such as the TyG-waist-to-height ratio (TyG-WHtR), provide reliable surrogate measures for estimating insulin resistance (IR). Their associations with renal function in hypertensive patients remain unclear. This study examined the associations of TyG-WHtR and its related indices with estimated glomerular filtration rate (eGFR) in a community-based elderly hypertensive population. METHODS: This cross-sectional study assessed the clinical indicators, TyG-related indices, and eGFR in a cohort of 3,764 hypertensive adults aged ≥65 years from Huaian, China, employing restricted cubic spline models (RCS), logistic regression, spearman correlation, and receiver operating characteristic (ROC) curve analyses to evaluate the associations and predictive utility of TyG-WHtR and related parameters for identifying impaired renal function, defined by reduced eGFR. RESULTS: A total of 612 participants (16.25%) had reduced eGFR. Significant predictors of reduced eGFR included elevated TyG-WHtR and related indices, with TyG-WHtR showing a particularly robust association in both pre- and post-adjustment analyses. These indices correlated negatively with high-density lipoprotein cholesterol (HDL-C), and positively with measures of adiposity, fasting plasma glucose (FPG), and non-HDL cholesterol. Significant interactions were found for gender, age, and alcohol consumption. TyG-WHtR alone had an AUC of 0.596, but after adjustment its predictive ability improved to 0.864, demonstrating superior performance compared to TyG, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC). CONCLUSION: Elevated TyG-WHtR is an independent risk factor for the decline in eGFR in elderly patients with hypertension, demonstrating superior predictive value compared to other TyG-related indices. TyG-WHtR may serve as a useful marker for early identification of renal dysfunction in this population.