Effects of Low-Intensity Aaerobic Training on Cardiac Dysfunction and Myocardial Fibrosis Induced by Doxorubicin in Wistar Rats.
TCR, P., ATF, S., MM, M., SR, D., BA, F., MM, d.G.P., PR, L., TM, M., TM, F., & YC, d.P.M. (2026). Effects of Low-Intensity Aaerobic Training on Cardiac Dysfunction and Myocardial Fibrosis Induced by Doxorubicin in Wistar Rats.. Cardiovascular toxicology. https://doi.org/10.1007/s12012-026-10150-7
TCR P, ATF S, MM M, SR D, BA F, MM dGP, et al. Effects of Low-Intensity Aaerobic Training on Cardiac Dysfunction and Myocardial Fibrosis Induced by Doxorubicin in Wistar Rats.. Cardiovascular toxicology. 2026; doi: 10.1007/s12012-026-10150-7
TCR P, ATF S, MM M, et al. Effects of Low-Intensity Aaerobic Training on Cardiac Dysfunction and Myocardial Fibrosis Induced by Doxorubicin in Wistar Rats.[J]. Cardiovascular toxicology. 2026. DOI: 10.1007/s12012-026-10150-7.
@article{tcr2026,
author = {Pereira TCR and Silva ATF and Mantovani MM and Deconte SR and Ferreira BA and da Guarda Pinto MM and Lopes PR and Menezes TM and Fidale TM and de Paiva Maia YC},
title = {Effects of Low-Intensity Aaerobic Training on Cardiac Dysfunction and Myocardial Fibrosis Induced by Doxorubicin in Wistar Rats.},
journal = {Cardiovascular toxicology},
year = {2026},
doi = {10.1007/s12012-026-10150-7},
note = {PMID: 42377634},
}
TY - JOUR AU - Pereira TCR AU - Silva ATF AU - Mantovani MM AU - Deconte SR AU - Ferreira BA AU - da Guarda Pinto MM AU - Lopes PR AU - Menezes TM AU - Fidale TM AU - de Paiva Maia YC TI - Effects of Low-Intensity Aaerobic Training on Cardiac Dysfunction and Myocardial Fibrosis Induced by Doxorubicin in Wistar Rats. T2 - Cardiovascular toxicology PY - 2026 DO - 10.1007/s12012-026-10150-7 AN - PMID:42377634 ER -
Doxorubicin-induced cardiotoxicity is a major limitation in cancer therapy. Physical exercise has been proposed as a non-pharmacological strategy capable of mitigating these effects through cardiovascular adaptations. This study evaluated whether low-intensity aerobic training attenuates cardiac dysfunction induced by doxorubicin. Twenty-five adult male Wistar rats (450 and 500 g) were allocated and divided into four groups: Control (C), Doxorubicin (D), Doxorubicin and Trained (DT), and Trained (T). The D and DT groups received weekly intraperitoneal injections of doxorubicin over a four-week period, totaling a cumulative dose of 8 mg/kg. The DT and T groups underwent low-intensity aerobic training for 25 weeks, three times a week, with sessions lasting 10 to 20 min at 50 and 60% of maximum aerobic speed. Statistical analysis was performed using GraphPad Prism software (version 8.0). The D group showed a significant increase in myocardial collagen deposition and a reduction in S wave values (parietal and septal) on echocardiography, compared to the control group. The values observed were 0.040 for group D and 0.065 for group C in the parietal S wave (overall p = 0.0248), and 0.040 for group D and 0.070 for group C in the septal S wave (overall p = 0.0389). Regarding exercise tolerance, group D showed the greatest reduction in performance from Test 0 to Test 5 (65.06%; p < 0.0001), followed by group C (23.60%; p = 0.0103). Group DT showed a smaller numerical reduction in performance (23.07%), but this change did not reach statistical significance (p = 0.1256), while group T showed a non-significant numerical improvement (10.99%; p = 0.2020). The results suggest that low-intensity aerobic training may attenuate cardiac fibrosis and partially preserve functional capacity in rats with doxorubicin-induced cardiotoxicity.