Association of Triglyceride-Glucose Index, Triglyceride/HDL Cholesterol Ratio and Metabolic Score for Insulin Resistance With Asymptomatic Organ Damage in Previously Untreated Patients With Hypertension.
I, P., A, T., S, S., TN, S., & E, M. (2026). Association of Triglyceride-Glucose Index, Triglyceride/HDL Cholesterol Ratio and Metabolic Score for Insulin Resistance With Asymptomatic Organ Damage in Previously Untreated Patients With Hypertension.. Journal of clinical hypertension (Greenwich, Conn.). https://doi.org/10.1111/jch.70323
I P, A T, S S, TN S, E M. Association of Triglyceride-Glucose Index, Triglyceride/HDL Cholesterol Ratio and Metabolic Score for Insulin Resistance With Asymptomatic Organ Damage in Previously Untreated Patients With Hypertension.. Journal of clinical hypertension (Greenwich, Conn.). 2026; doi: 10.1111/jch.70323
I P, A T, S S, et al. Association of Triglyceride-Glucose Index, Triglyceride/HDL Cholesterol Ratio and Metabolic Score for Insulin Resistance With Asymptomatic Organ Damage in Previously Untreated Patients With Hypertension.[J]. Journal of clinical hypertension (Greenwich, Conn.). 2026. DOI: 10.1111/jch.70323.
@article{i2026,
author = {Papasotiriou I and Tentolouris A and Spiliopoulou S and Sergentanis TN and Manios E},
title = {Association of Triglyceride-Glucose Index, Triglyceride/HDL Cholesterol Ratio and Metabolic Score for Insulin Resistance With Asymptomatic Organ Damage in Previously Untreated Patients With Hypertension.},
journal = {Journal of clinical hypertension (Greenwich, Conn.)},
year = {2026},
doi = {10.1111/jch.70323},
note = {PMID: 42381204},
}
TY - JOUR AU - Papasotiriou I AU - Tentolouris A AU - Spiliopoulou S AU - Sergentanis TN AU - Manios E TI - Association of Triglyceride-Glucose Index, Triglyceride/HDL Cholesterol Ratio and Metabolic Score for Insulin Resistance With Asymptomatic Organ Damage in Previously Untreated Patients With Hypertension. T2 - Journal of clinical hypertension (Greenwich, Conn.) PY - 2026 DO - 10.1111/jch.70323 AN - PMID:42381204 ER -
We aimed to examine the association between insulin resistance (IR) and target organ damage (TOD) in patients with hypertension. Three indices of IR (Triglyceride-Glucose index: TyG; triglyceride-to-HDL ratio: TG/HDL-C; Metabolic Score for Insulin Resistance: METS-IR) were examined for their association with TOD in 614 newly diagnosed patients with hypertension. Left ventricular mass index (LVMI), the intima-media thickness of the common carotid artery (IMT-CCA) and estimated Glomerular Filtration Rate (eGFR) were used as indices of cardiac, artery and renal damage. Receiver Operating Characteristic (ROC) analysis performed to estimate optimal cut-off for each index, while simple and multiple logistic regression models were applied to examine the indices as binary predictors of organ damage. Linear and non-linear associations were examined with continuous variables using linear regression and restricted cubic splines (RCS) models. After adjusting for confounders, logistic regression showed that high TG/HDL-C (OR:1.50, 95%CI:1.03-2.18) and METS-IR (OR:2.17, 95%CI:1.50-3.13) were associated with increased risk of left ventricular hypertrophy, while only high METS-IR was associated with increased risk of carotid plaque (OR:2.07, 95%CI:1.17-3.68) and only high TG/HDL-C was associated with renal damage (OR:2.33, 95%CI:1.02-5.36). Adjusted linear regression showed that none of the indices were significantly associated with LVMI. However, all indices were associated with CCA-IMT (p < 0.05), but none with eGFR (p > 0.05). Adjusted RCS models showed a significant non-linear association between TyG and CCA-IMT (p for non-linearity = 0.009). In conclusion, IR biomarkers are of clinical value in newly diagnosed patients with hypertension.