[Heart-brain interaction: mechanisms and therapeutic strategies from integrated TCM and western medicine].
JF, W. & QL, L. (2026). [Heart-brain interaction: mechanisms and therapeutic strategies from integrated TCM and western medicine].. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. https://doi.org/10.19540/j.cnki.cjcmm.20260120.501
JF W, QL L. [Heart-brain interaction: mechanisms and therapeutic strategies from integrated TCM and western medicine].. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2026; doi: 10.19540/j.cnki.cjcmm.20260120.501
JF W, QL L. [Heart-brain interaction: mechanisms and therapeutic strategies from integrated TCM and western medicine].[J]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2026. DOI: 10.19540/j.cnki.cjcmm.20260120.501.
@article{jf2026,
author = {Wu JF and Lyu QL},
title = {[Heart-brain interaction: mechanisms and therapeutic strategies from integrated TCM and western medicine].},
journal = {Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica},
year = {2026},
doi = {10.19540/j.cnki.cjcmm.20260120.501},
note = {PMID: 42392798},
}
TY - JOUR AU - Wu JF AU - Lyu QL TI - [Heart-brain interaction: mechanisms and therapeutic strategies from integrated TCM and western medicine]. T2 - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica PY - 2026 DO - 10.19540/j.cnki.cjcmm.20260120.501 AN - PMID:42392798 ER -
Cardiovascular and cerebrovascular diseases have a high global incidence and are major causes of disability and mortality. This review integrates perspectives from both TCM and modern medicine. Based on the TCM theory of "heart-brain homology", it comprehensively analyzes the effects of cardiovascular risk factors and cerebral lesions on the heart-brain axis. A three-dimensional regulatory axis is proposed, encompassing metabolic reprogramming, inflammatory-oxidative cascade reactions, and epigenetic regulation mediated by ten-eleven translocation methylcytosine dioxygenases(TET enzymes). Furthermore, the protective effects of multi-target therapeutic agents, including statins, sodium-glucose cotransporter 2(SGLT2) inhibitors, and TCM preparations such as Tongxinluo Capsules and Naoxintong Capsules, on the cardiovascular and nervous systems are discussed. Future directions include artificial intelligence(AI)-assisted drug discovery and novel drug delivery platforms(e.g., functional hydrogels and nanocarriers), which offer promising strategies for heart-brain targeted therapy.