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DTX1 Regulates Aortic Dissection Progression by Modulating Vascular Smooth Muscle Cell Phenotypic Switching via Ubiquitination of ITGA5.

期刊: Cardiovascular drugs and therapy 日期: 2026-05-06 PMID: 42090073 浏览: 57
作者: Wang Dong, Yang Lingbo, Zong Junqing
Dong, W., Lingbo, Y., & Junqing, Z. (2026). DTX1 Regulates Aortic Dissection Progression by Modulating Vascular Smooth Muscle Cell Phenotypic Switching via Ubiquitination of ITGA5.. Cardiovascular drugs and therapy.
Dong W, Lingbo Y, Junqing Z. DTX1 Regulates Aortic Dissection Progression by Modulating Vascular Smooth Muscle Cell Phenotypic Switching via Ubiquitination of ITGA5.. Cardiovascular drugs and therapy. 2026; PMID: 42090073
Dong W, Lingbo Y, Junqing Z. DTX1 Regulates Aortic Dissection Progression by Modulating Vascular Smooth Muscle Cell Phenotypic Switching via Ubiquitination of ITGA5.[J]. Cardiovascular drugs and therapy. 2026.
@article{dong2026,
  author = {Wang Dong and Yang Lingbo and Zong Junqing},
  title = {DTX1 Regulates Aortic Dissection Progression by Modulating Vascular Smooth Muscle Cell Phenotypic Switching via Ubiquitination of ITGA5.},
  journal = {Cardiovascular drugs and therapy},
  year = {2026},
  note = {PMID: 42090073},
}
TY  - JOUR
AU  - Wang Dong
AU  - Yang Lingbo
AU  - Zong Junqing
TI  - DTX1 Regulates Aortic Dissection Progression by Modulating Vascular Smooth Muscle Cell Phenotypic Switching via Ubiquitination of ITGA5.
T2  - Cardiovascular drugs and therapy
PY  - 2026
AN  - PMID:42090073
ER  - 

摘要

Aortic dissection (AD) is a life-threatening vascular disorder characterized by medial degeneration and phenotypic switching of vascular smooth muscle cells (VSMCs). While integrin subunit alpha 5 (ITGA5) has been implicated in VSMC plasticity, the upstream molecular mechanisms governing its regulation remain poorly defined.

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