Conjoint association of gestational diabetes mellitus and hypertensive disorders of pregnancy with long-term risk of mortality: a population-based cohort study.
D, G., Y, Z., Y, G., J, L., C, L., J, L., Y, P., W, Z., Y, W., & M, J. (2026). Conjoint association of gestational diabetes mellitus and hypertensive disorders of pregnancy with long-term risk of mortality: a population-based cohort study.. Journal of global health. https://doi.org/10.7189/jogh.16.04204
D G, Y Z, Y G, J L, C L, J L, et al. Conjoint association of gestational diabetes mellitus and hypertensive disorders of pregnancy with long-term risk of mortality: a population-based cohort study.. Journal of global health. 2026; doi: 10.7189/jogh.16.04204
D G, Y Z, Y G, et al. Conjoint association of gestational diabetes mellitus and hypertensive disorders of pregnancy with long-term risk of mortality: a population-based cohort study.[J]. Journal of global health. 2026. DOI: 10.7189/jogh.16.04204.
@article{d2026,
author = {Gao D and Zhang Y and Gao Y and Li J and Li C and Liang J and Pan Y and Zhang W and Wang Y and Ji M},
title = {Conjoint association of gestational diabetes mellitus and hypertensive disorders of pregnancy with long-term risk of mortality: a population-based cohort study.},
journal = {Journal of global health},
year = {2026},
doi = {10.7189/jogh.16.04204},
note = {PMID: 42396899},
}
TY - JOUR AU - Gao D AU - Zhang Y AU - Gao Y AU - Li J AU - Li C AU - Liang J AU - Pan Y AU - Zhang W AU - Wang Y AU - Ji M TI - Conjoint association of gestational diabetes mellitus and hypertensive disorders of pregnancy with long-term risk of mortality: a population-based cohort study. T2 - Journal of global health PY - 2026 DO - 10.7189/jogh.16.04204 AN - PMID:42396899 ER -
BACKGROUND: Gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDPs) are common maternal complications. We sought to evaluate the independent and joint association of GDM and HDPs with all-cause, premature, and cause-specific mortality. METHODS: We used data from the UK Biobank, which included 220 953 women who reported at least one live birth. Individual and joint associations of GDM and HDPs with all-cause, premature, and cause-specific mortality were estimated using Cox regression models. RESULTS: During a follow-up of 12.9 years, women who experienced GDM had a higher risk of all-cause (hazard ratio (HR) = 1.57; 95% confidence interval (CI) = 1.26-1.96), premature (HR = 1.60; 95% CI = 1.24-2.06) and cardiovascular disease (CVD) mortality (HR = 2.60; 95% CI = 1.70-3.96). Women with a history of HDPs had an increased risk for CVD mortality (HR = 2.07; 95% CI = 1.51-2.83), but the association with all-cause death and premature death was not significant. Individuals who encountered both GDM and HDPs had a 3.9-fold higher relative risk of all-cause mortality (HR = 3.93; 95% CI = 1.88-8.24]) and a 4.3-fold higher risk of premature mortality (HR = 4.31; 95% CI = 1.94-9.57), compared to those without GDM or HDPs. CONCLUSIONS: Women with GDM have a higher risk of all-cause, premature mortality and both risks were higher than the impacts of a history of HDPs based on a large-scale population. The co-occurrence of GDM and HDPs will deteriorate the aforementioned situation compared to a single cardiometabolic pregnancy complication.