Lesley, S., Janice, H., Sharon, G., Jeanine, R., Gordon, C., Sarah, B., Kara-Louise, R., Sadie, R., Catherine, O., Chris, P., Katie, S., Shelagh, T., & A, C.D. (2026). Blood Cancer Clinical Trials Long-term Follow-up Using Integrated Healthcare Systems Data (BLISS): protocol for a data-linkage study integrating randomised clinical trials with national healthcare systems data.. BMJ open.
Lesley S, Janice H, Sharon G, Jeanine R, Gordon C, Sarah B, et al. Blood Cancer Clinical Trials Long-term Follow-up Using Integrated Healthcare Systems Data (BLISS): protocol for a data-linkage study integrating randomised clinical trials with national healthcare systems data.. BMJ open. 2026; PMID: 42114877
Lesley S, Janice H, Sharon G, et al. Blood Cancer Clinical Trials Long-term Follow-up Using Integrated Healthcare Systems Data (BLISS): protocol for a data-linkage study integrating randomised clinical trials with national healthcare systems data.[J]. BMJ open. 2026.
@article{lesley2026,
author = {Smith Lesley and Hoang Janice and Gillson Sharon and Richards Jeanine and Cook Gordon and Brown Sarah and Royle Kara-Louise and Roberts Sadie and Olivier Catherine and Parish Chris and Spencer Katie and Thompson Shelagh and Cairns David A},
title = {Blood Cancer Clinical Trials Long-term Follow-up Using Integrated Healthcare Systems Data (BLISS): protocol for a data-linkage study integrating randomised clinical trials with national healthcare systems data.},
journal = {BMJ open},
year = {2026},
note = {PMID: 42114877},
}
TY - JOUR AU - Smith Lesley AU - Hoang Janice AU - Gillson Sharon AU - Richards Jeanine AU - Cook Gordon AU - Brown Sarah AU - Royle Kara-Louise AU - Roberts Sadie AU - Olivier Catherine AU - Parish Chris AU - Spencer Katie AU - Thompson Shelagh AU - Cairns David A TI - Blood Cancer Clinical Trials Long-term Follow-up Using Integrated Healthcare Systems Data (BLISS): protocol for a data-linkage study integrating randomised clinical trials with national healthcare systems data. T2 - BMJ open PY - 2026 AN - PMID:42114877 ER -
Randomised clinical trials (RCTs) are gold standard in evidence-based medicine, but follow-up typically relies on clinic visits and trial-specific data collection. Much of this information overlaps with routinely collected healthcare systems data (HSD), such as electronic health records and national registries. Leveraging HSD for trial follow-up has the potential to reduce cost, time and resource burden. However, concerns remain about data quality and evidence is needed to show that HSD-based outcomes are reported to an equivalent standard to trial-specific data.The Blood Cancer Clinical Trials Long-term Follow-up Using Integrated Healthcare Systems platform will link data collected from multiple myeloma clinical trials with HSD to create a research database supporting extended follow-up and further methodological and clinical research.