Glycosaminoglycans and Their Role in Capillary Walls.
LK, M. & KP, A. (2026). Glycosaminoglycans and Their Role in Capillary Walls.. Advances in experimental medicine and biology. https://doi.org/10.1007/978-3-032-22285-5_3
LK M, KP A. Glycosaminoglycans and Their Role in Capillary Walls.. Advances in experimental medicine and biology. 2026; doi: 10.1007/978-3-032-22285-5_3
LK M, KP A. Glycosaminoglycans and Their Role in Capillary Walls.[J]. Advances in experimental medicine and biology. 2026. DOI: 10.1007/978-3-032-22285-5_3.
@article{lk2026,
author = {Milne LK and Arkill KP},
title = {Glycosaminoglycans and Their Role in Capillary Walls.},
journal = {Advances in experimental medicine and biology},
year = {2026},
doi = {10.1007/978-3-032-22285-5_3},
note = {PMID: 42420703},
}
TY - JOUR AU - Milne LK AU - Arkill KP TI - Glycosaminoglycans and Their Role in Capillary Walls. T2 - Advances in experimental medicine and biology PY - 2026 DO - 10.1007/978-3-032-22285-5_3 AN - PMID:42420703 ER -
Glycosaminoglycans (GAGs) are polysaccharide chains that extend into the vascular lumen and are embedded throughout the capillary wall. They have a multitude of biophysical and biochemical roles including control of vascular permeability, shear stress detection and growth factor uptake. The spatial distribution of GAGs is key to their function and, when coupled to their post-transcriptional synthesis, becomes technically challenging to analyse in model systems. This chapter brings together the evidence for their role in capillary permeability using the glomerular filtration barrier as an example. We also discuss methods, and potential methods, of in situ capillary scale imaging and analysis.