Examining the association between cardiovascular outcomes in individuals undergoing percutaneous coronary intervention with or without a preceding coronary CT angiogram.
Khalid, S., Bhupendar, T., Hay, K.K., Aakash, R., Brad, F., F, S.R., Landon, B., Kedar, J., Jennifer, R., S, D.P., & J, A.S. (2026). Examining the association between cardiovascular outcomes in individuals undergoing percutaneous coronary intervention with or without a preceding coronary CT angiogram.. Eur Heart J Imaging Methods Pract. https://doi.org/10.1093/ehjimp/qyag062
Khalid S, Bhupendar T, Hay KK, Aakash R, Brad F, F SR, et al. Examining the association between cardiovascular outcomes in individuals undergoing percutaneous coronary intervention with or without a preceding coronary CT angiogram.. Eur Heart J Imaging Methods Pract. 2026; doi: 10.1093/ehjimp/qyag062
Khalid S, Bhupendar T, Hay KK, et al. Examining the association between cardiovascular outcomes in individuals undergoing percutaneous coronary intervention with or without a preceding coronary CT angiogram.[J]. Eur Heart J Imaging Methods Pract. 2026. DOI: 10.1093/ehjimp/qyag062.
@article{khalid2026,
author = {Sawalha Khalid and Tayal Bhupendar and Kragholm Kristian Hay and Rana Aakash and Fugere Brad and Spraggins Robert F and Bruich Landon and Jambhekar Kedar and Rymer Jennifer and Douglas Pamela S and Al'Aref Subhi J},
title = {Examining the association between cardiovascular outcomes in individuals undergoing percutaneous coronary intervention with or without a preceding coronary CT angiogram.},
journal = {Eur Heart J Imaging Methods Pract},
year = {2026},
doi = {10.1093/ehjimp/qyag062},
note = {PMID: 42058587},
}
TY - JOUR AU - Sawalha Khalid AU - Tayal Bhupendar AU - Kragholm Kristian Hay AU - Rana Aakash AU - Fugere Brad AU - Spraggins Robert F AU - Bruich Landon AU - Jambhekar Kedar AU - Rymer Jennifer AU - Douglas Pamela S AU - Al'Aref Subhi J TI - Examining the association between cardiovascular outcomes in individuals undergoing percutaneous coronary intervention with or without a preceding coronary CT angiogram. T2 - Eur Heart J Imaging Methods Pract PY - 2026 DO - 10.1093/ehjimp/qyag062 AN - PMID:42058587 ER -
The role of coronary CT angiography (CCTA) in improving outcomes among patients undergoing percutaneous coronary intervention (PCI) for obstructive coronary artery disease (CAD) remains unclear. A retrospective cohort study using the TriNetX U.S. Research Network identified adults (≥18 years) who underwent de novo PCI (2013-2025). Patients with prior or presenting PCI, coronary artery bypass grafting, or acute coronary syndrome were excluded. Those with CCTA within 1 year before PCI were compared to those without CCTA. After 1:1 propensity score matching, 4936 patients remained in each group. The primary outcome was a composite of all-cause mortality, myocardial infarction (MI), or heart failure (HF) at 1 and 5 years. Baseline characteristics were well-balanced post-matching. CCTA prior to PCI was associated with lower rates of the composite outcome at 1 year (9.6% vs. 13.0%; hazard ratios (HR) 0.74, 95% CI 0.66-0.83) and 5 years (16.1% vs. 23.7%; HR 0.79, 95% CI 0.72-0.86). Reductions were mainly driven by lower MI and mortality rates. HF showed no difference at 1 year but was significantly lower at 5 years (HR 0.85, 95% CI 0.76-0.95). Pre-procedural CCTA within 1 year of PCI was associated with improved cardiovascular outcomes at 1 and 5 years, suggesting potential benefits from enhanced anatomical assessment and medical optimization before revascularization.