Hypertension up-regulates yes-associated protein expression in the penile corpus cavernosum and suppresses erectile function in spontaneously hypertensive rats.
Y, L., F, W., J, J., & R, J. (2026). Hypertension up-regulates yes-associated protein expression in the penile corpus cavernosum and suppresses erectile function in spontaneously hypertensive rats.. The journal of sexual medicine. https://doi.org/10.1093/jsxmed/qdag219
Y L, F W, J J, R J. Hypertension up-regulates yes-associated protein expression in the penile corpus cavernosum and suppresses erectile function in spontaneously hypertensive rats.. The journal of sexual medicine. 2026; doi: 10.1093/jsxmed/qdag219
Y L, F W, J J, et al. Hypertension up-regulates yes-associated protein expression in the penile corpus cavernosum and suppresses erectile function in spontaneously hypertensive rats.[J]. The journal of sexual medicine. 2026. DOI: 10.1093/jsxmed/qdag219.
@article{y2026,
author = {Li Y and Wang F and Jiang J and Jiang R},
title = {Hypertension up-regulates yes-associated protein expression in the penile corpus cavernosum and suppresses erectile function in spontaneously hypertensive rats.},
journal = {The journal of sexual medicine},
year = {2026},
doi = {10.1093/jsxmed/qdag219},
note = {PMID: 42430781},
}
TY - JOUR AU - Li Y AU - Wang F AU - Jiang J AU - Jiang R TI - Hypertension up-regulates yes-associated protein expression in the penile corpus cavernosum and suppresses erectile function in spontaneously hypertensive rats. T2 - The journal of sexual medicine PY - 2026 DO - 10.1093/jsxmed/qdag219 AN - PMID:42430781 ER -
INTRODUCTION: Hypertension is an important risk factor for erectile dysfunction. Yes-associated protein (YAP) is a multifunctional protein involved in diverse biological processes; whether hypertension influences erectile function through the regulation of YAP remains unclear; therefore, this study investigated whether hypertension impairs erectile function in spontaneously hypertensive rats (SHR) by upregulating YAP expression in the penile corpus cavernosum. METHODS: Twelve 8-week-old male WKY rats were randomly divided into the WKY group and the WKY + LV group (n = 6), and twenty-four 8-week-old male SHR rats were randomly divided into four groups: the SHR group, SHR + NC group, SHR + LV group, and SHR + RES group (n = 6). SHR + RES group received resveratrol (10 mg/kg/d) by gavage for 4 weeks, and the WKY + LV,SHR + LV and SHR + NC groups were treated with a single intracavernosal injection of YAP siRNA lentivirus or empty vector (20 μL/rat, 1 × 109 TU/mL) at week 4. One week later, ICPmax/MAP, serum testosterone, NO, and expression of YAP, Caspase-1, Gasdermin D-N, Caspase-3, and p-eNOS/eNOS in the corpus cavernosum were measured. RESULTS: YAP was predominantly expressed in the cytoplasm and nuclei of endothelial cells in the corpus cavernosum. Compared with the WKY group, the SHR group showed significantly lower NO levels, ICPmax/MAP, and p-eNOS/eNOS expression, but significantly higher expression of YAP, Caspase-1, GSDMD-N, and Caspase-3. In contrast, both the SHR + LV and SHR + RES groups showed significantly increased NO levels and ICPmax/MAP, decreased YAP, Caspase-1, GSDMD-N, and Caspase-3 expression, and reduced endothelial apoptosis and pyroptosis compared with the SHR group (P < .05). DISCUSSION: Hypertension impairs erectile function by upregulating YAP expression in the penile corpus cavernosum, thereby promoting endothelial apoptosis and pyroptosis and reducing p-eNOS/eNOS and NO production, whereas resveratrol may ameliorate these changes by suppressing YAP expression.