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Conserved Transcriptional Circuits Regulate Cardiac Fibroblast-Mediated Fibrosis.

期刊: Circulation research 日期: 2026-06-19 PMID: 42125800 浏览: 38
作者: Krstevski, Farrugia, Hsu, Dona, Gaynor, Cohen, Harper, Harrison, Raffaut, Claridge, Drack, Lelliott, Brown, McMullen, Donner, Lal, Greening, Pinto
Krstevski, Farrugia, Hsu, Dona, Gaynor, Cohen, Harper, Harrison, Raffaut, Claridge, Drack, Lelliott, Brown, McMullen, Donner, Lal, Greening, & Pinto (2026). Conserved Transcriptional Circuits Regulate Cardiac Fibroblast-Mediated Fibrosis.. Circulation research.
Krstevski, Farrugia, Hsu, Dona, Gaynor, Cohen, et al. Conserved Transcriptional Circuits Regulate Cardiac Fibroblast-Mediated Fibrosis.. Circulation research. 2026; PMID: 42125800
Krstevski, Farrugia, Hsu, et al. Conserved Transcriptional Circuits Regulate Cardiac Fibroblast-Mediated Fibrosis.[J]. Circulation research. 2026.
@article{krstevski2026,
  author = {Krstevski and Farrugia and Hsu and Dona and Gaynor and Cohen and Harper and Harrison and Raffaut and Claridge and Drack and Lelliott and Brown and McMullen and Donner and Lal and Greening and Pinto},
  title = {Conserved Transcriptional Circuits Regulate Cardiac Fibroblast-Mediated Fibrosis.},
  journal = {Circulation research},
  year = {2026},
  note = {PMID: 42125800},
}
TY  - JOUR
AU  - Krstevski
AU  - Farrugia
AU  - Hsu
AU  - Dona
AU  - Gaynor
AU  - Cohen
AU  - Harper
AU  - Harrison
AU  - Raffaut
AU  - Claridge
AU  - Drack
AU  - Lelliott
AU  - Brown
AU  - McMullen
AU  - Donner
AU  - Lal
AU  - Greening
AU  - Pinto
TI  - Conserved Transcriptional Circuits Regulate Cardiac Fibroblast-Mediated Fibrosis.
T2  - Circulation research
PY  - 2026
AN  - PMID:42125800
ER  - 

摘要

Cardiac fibrosis is a major cause of cardiac dysfunction and is associated with virtually all forms of heart disease. Recently, single-cell genomic approaches have revealed in unprecedented resolution the orchestrated cellular responses driving cardiac fibrosis. Yet, the fibrosis-inducing phenotypes that emerge in the heart after nonischemic cardiac stress and the transcriptional circuits that govern fibrogenic cellular phenotypes are not well understood.

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