Correlation study of serum vitamin K and Gas6 levels with aortic arch calcification and left ventricular hypertrophy in maintenance hemodialysis patients.
M, G. & J, W. (2026). Correlation study of serum vitamin K and Gas6 levels with aortic arch calcification and left ventricular hypertrophy in maintenance hemodialysis patients.. Pakistan journal of pharmaceutical sciences. https://doi.org/10.36721/PJPS.2026.39.9.249.1
M G, J W. Correlation study of serum vitamin K and Gas6 levels with aortic arch calcification and left ventricular hypertrophy in maintenance hemodialysis patients.. Pakistan journal of pharmaceutical sciences. 2026; doi: 10.36721/PJPS.2026.39.9.249.1
M G, J W. Correlation study of serum vitamin K and Gas6 levels with aortic arch calcification and left ventricular hypertrophy in maintenance hemodialysis patients.[J]. Pakistan journal of pharmaceutical sciences. 2026. DOI: 10.36721/PJPS.2026.39.9.249.1.
@article{m2026,
author = {Gan M and Wang J},
title = {Correlation study of serum vitamin K and Gas6 levels with aortic arch calcification and left ventricular hypertrophy in maintenance hemodialysis patients.},
journal = {Pakistan journal of pharmaceutical sciences},
year = {2026},
doi = {10.36721/PJPS.2026.39.9.249.1},
note = {PMID: 42436623},
}
TY - JOUR AU - Gan M AU - Wang J TI - Correlation study of serum vitamin K and Gas6 levels with aortic arch calcification and left ventricular hypertrophy in maintenance hemodialysis patients. T2 - Pakistan journal of pharmaceutical sciences PY - 2026 DO - 10.36721/PJPS.2026.39.9.249.1 AN - PMID:42436623 ER -
BACKGROUND: Cardiovascular disease is the leading cause of death among MHD patients, with aortic arch calcification and left ventricular hypertrophy as common complications. The role of vitamin K-dependent protein Gas6 in these structural changes remains unclear. OBJECTIVES: To examine the relationship between serum vitamin K2/Gas6 levels and the presence of aortic arch calcification/left ventricular hypertrophy in MHD patients. METHODS: This cross-sectional study enrolled 189 patients with MHD. Serum vitamin K2 (MK-7) and Gas6 levels were quantified using enzyme-linked immunosorbent assay (ELISA). LVMI stratified patients into LVH (n=110) and non-LVH (n=79) groups, and by AACS into four calcification severity groups (n=46, 54, 53, 36). Group differences were analyzed using Spearman correlation and multivariate logistic regression. RESULTS: LVH patients were older and had higher BNP, creatinine and Gas6 levels, but lower vitamin K2 levels (P<0.05). Across AACS groups, age, glucose, phosphorus, calcium-phosphorus product, vitamin K2 and Gas6 differed significantly. Vitamin K2 correlated positively with calcium (r=0.822) and negatively with Gas6 (r= -0.339). Age >65 years and vitamin K2 <2.39 nmol/L were independent AACS risk factors. CONCLUSION: No correlation was found between serum vitamin K or Gas6 and LVH in MHD patients. AACS negatively correlated with vitamin K and positively with Gas6.