Association of Systemic Hemodynamics and Endothelial Dysfunction With Clinical Phenotypes in Sensorineural Hearing Loss With Vertigo: A Cross-Sectional Analysis.
D, G., W, Y., Z, W., H, Z., X, Z., & T, Y. (2026). Association of Systemic Hemodynamics and Endothelial Dysfunction With Clinical Phenotypes in Sensorineural Hearing Loss With Vertigo: A Cross-Sectional Analysis.. Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgi. https://doi.org/10.1177/19160216261454997
D G, W Y, Z W, H Z, X Z, T Y. Association of Systemic Hemodynamics and Endothelial Dysfunction With Clinical Phenotypes in Sensorineural Hearing Loss With Vertigo: A Cross-Sectional Analysis.. Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgi. 2026; doi: 10.1177/19160216261454997
D G, W Y, Z W, et al. Association of Systemic Hemodynamics and Endothelial Dysfunction With Clinical Phenotypes in Sensorineural Hearing Loss With Vertigo: A Cross-Sectional Analysis.[J]. Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgi. 2026. DOI: 10.1177/19160216261454997.
@article{d2026,
author = {Geng D and Yuan W and Wang Z and Zhang H and Zhao X and Yang T},
title = {Association of Systemic Hemodynamics and Endothelial Dysfunction With Clinical Phenotypes in Sensorineural Hearing Loss With Vertigo: A Cross-Sectional Analysis.},
journal = {Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgi},
year = {2026},
doi = {10.1177/19160216261454997},
note = {PMID: 42439328},
}
TY - JOUR AU - Geng D AU - Yuan W AU - Wang Z AU - Zhang H AU - Zhao X AU - Yang T TI - Association of Systemic Hemodynamics and Endothelial Dysfunction With Clinical Phenotypes in Sensorineural Hearing Loss With Vertigo: A Cross-Sectional Analysis. T2 - Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgi PY - 2026 DO - 10.1177/19160216261454997 AN - PMID:42439328 ER -
IMPORTANCE: Sensorineural hearing loss (SNHL) accompanied by vertigo is a condition with clinical heterogeneity. Understanding vascular underpinnings is crucial for management. OBJECTIVE: To investigate the association of systemic hemodynamics and endothelial dysfunction with the distinct clinical manifestations of SNHL with vertigo. DESIGN: A descriptive, hospital-based cross-sectional study. SETTING: Department of Otolaryngology Head and Neck Surgery at a tertiary academic hospital. PARTICIPANTS: One hundred forty-two consecutive patients with SNHL and vertigo (disease duration ≤30 days) enrolled between January 2023 and October 2025. INTERVENTION: Observational study; no intervention was performed. MAIN OUTCOME MEASURES: Pure-tone audiometry (PTA) including high-frequency thresholds (6-8 kHz), Dizziness Handicap Inventory (DHI), Tinnitus Evaluation Questionnaire, transcranial Doppler for mean flow velocity (Vm), and serum endothelin-1 (ET-1)/nitric oxide (NO). Linear regression analyzed associations. RESULTS: Linear regression showed PTA was significantly predicted by higher ET-1 (R2 = .37, P < .001) and lower NO. DHI was predicted by lower Vm (R2 = .40, P < .001). High-frequency PTA (6-8 kHz) was significantly worse in the Hearing Loss-Dominant (HLD) group (P < .001). The HLD group (n = 75) exhibited significantly higher ET-1 levels compared to the Vertigo-Dominant (VD) group (n = 67) (85.4 vs 73.1 pg/mL, P < .001). Conversely, the VD group showed a more pronounced reduction in Vm (33.2 vs 38.5 cm/s, P < .001). Multiple linear regression identified ET-1 as the strongest predictor for PTA and Vm for DHI score. CONCLUSIONS: Systemic hemodynamic compromise and endothelial dysfunction differentially associate with hearing and vestibular phenotypes. Cochlear symptoms may be driven by endothelial-mediated vasoconstriction, while vestibular symptoms are more sensitive to macrovascular flow reduction. RELEVANCE: Vascular profiling could inform targeted therapeutic strategies.