Schwartz, Winbo, Sala, Crotti, Musu, Dagradi, Giovenzana, Dragani, Sjödin, S., Lundström, Alberio, Pedrazzini, Nearing, Rydberg, Tse, Badilini, Verrier, Spazzolini, & Gnecchi (2026). MTMR4 variants have opposite gene-specific impact on life-threatening arrhythmic risk in type 1 and 2 long QT syndrome.. European heart journal.
Schwartz, Winbo, Sala, Crotti, Musu, Dagradi, et al. MTMR4 variants have opposite gene-specific impact on life-threatening arrhythmic risk in type 1 and 2 long QT syndrome.. European heart journal. 2026; PMID: 42128250
Schwartz, Winbo, Sala, et al. MTMR4 variants have opposite gene-specific impact on life-threatening arrhythmic risk in type 1 and 2 long QT syndrome.[J]. European heart journal. 2026.
@article{schwartz2026,
author = {Schwartz and Winbo and Sala and Crotti and Musu and Dagradi and Giovenzana and Dragani and Simonyté Sjödin and Lundström and Alberio and Pedrazzini and Nearing and Rydberg and Tse and Badilini and Verrier and Spazzolini and Gnecchi},
title = {MTMR4 variants have opposite gene-specific impact on life-threatening arrhythmic risk in type 1 and 2 long QT syndrome.},
journal = {European heart journal},
year = {2026},
note = {PMID: 42128250},
}
TY - JOUR AU - Schwartz AU - Winbo AU - Sala AU - Crotti AU - Musu AU - Dagradi AU - Giovenzana AU - Dragani AU - Simonyté Sjödin AU - Lundström AU - Alberio AU - Pedrazzini AU - Nearing AU - Rydberg AU - Tse AU - Badilini AU - Verrier AU - Spazzolini AU - Gnecchi TI - MTMR4 variants have opposite gene-specific impact on life-threatening arrhythmic risk in type 1 and 2 long QT syndrome. T2 - European heart journal PY - 2026 AN - PMID:42128250 ER -
Modifier genes may cause different clinical phenotypes in patients with long QT syndrome (LQTS) carrying the same pathogenic variant. Variants in the MTMR4 gene have been previously associated, via patient-specific cardiomyocytes derived from induced pluripotent stem cells, with variable arrhythmic risk in a family with the p.Y111C-LQT1 mutation. This study aimed to evaluate the broader clinical impact of MTMR4 variants in patients with LQT1 and LQT2.