A Dysbiosis-Urolithin A Depletion-Low 6-Sulfatoxymelatonin Triad as a Composite Biomarker Framework Across Age-Related Vascular and Malignant Disease States.
A, T., L, T., G, S., M, B., RJ, R., R, L., D, K., N, O., P, R., & I, A. (2026). A Dysbiosis-Urolithin A Depletion-Low 6-Sulfatoxymelatonin Triad as a Composite Biomarker Framework Across Age-Related Vascular and Malignant Disease States.. International journal of molecular sciences. https://doi.org/10.3390/ijms27135753
A T, L T, G S, M B, RJ R, R L, et al. A Dysbiosis-Urolithin A Depletion-Low 6-Sulfatoxymelatonin Triad as a Composite Biomarker Framework Across Age-Related Vascular and Malignant Disease States.. International journal of molecular sciences. 2026; doi: 10.3390/ijms27135753
A T, L T, G S, et al. A Dysbiosis-Urolithin A Depletion-Low 6-Sulfatoxymelatonin Triad as a Composite Biomarker Framework Across Age-Related Vascular and Malignant Disease States.[J]. International journal of molecular sciences. 2026. DOI: 10.3390/ijms27135753.
@article{a2026,
author = {Tavartkiladze A and Tavartkiladze L and Simonia G and Burnier M and Reiter RJ and Lou R and Kasradze D and Okrostsvaridze N and Revazishvili P and Andronikashvili I},
title = {A Dysbiosis-Urolithin A Depletion-Low 6-Sulfatoxymelatonin Triad as a Composite Biomarker Framework Across Age-Related Vascular and Malignant Disease States.},
journal = {International journal of molecular sciences},
year = {2026},
doi = {10.3390/ijms27135753},
note = {PMID: 42450025},
}
TY - JOUR AU - Tavartkiladze A AU - Tavartkiladze L AU - Simonia G AU - Burnier M AU - Reiter RJ AU - Lou R AU - Kasradze D AU - Okrostsvaridze N AU - Revazishvili P AU - Andronikashvili I TI - A Dysbiosis-Urolithin A Depletion-Low 6-Sulfatoxymelatonin Triad as a Composite Biomarker Framework Across Age-Related Vascular and Malignant Disease States. T2 - International journal of molecular sciences PY - 2026 DO - 10.3390/ijms27135753 AN - PMID:42450025 ER -
Urolithin A (UA) is a gut microbiota-derived postbiotic generated from dietary ellagitannins, while urinary 6-sulfatoxymelatonin (6-SMT) is a surrogate marker of nocturnal melatonin output. We explored whether dysbiosis, UA depletion, and low 6-SMT define an ordered biomarker pattern across healthy aging, salt-sensitive hypertension, and advanced cancer. In this pilot observational study, patients with advanced solid tumors were classified as Cancer Group 1 (higher aggressiveness; n = 231) or Cancer Group 2 (lower aggressiveness; n = 118) and compared with healthy older controls (n = 117) and elderly participants with salt-sensitive hypertension (n = 333). Plasma UA decreased stepwise from controls (2.24 [1.38-3.12] nmol/L) to salt-sensitive hypertension (1.20 [0.76-1.89] nmol/L), Cancer Group 2 (0.60 [0.32-0.91] nmol/L), and Cancer Group 1, in which most samples were at or below the assay limit (overall p < 0.0001; trend p < 0.0001). Twenty-four-hour urinary 6-SMT declined in parallel, whereas the dysbiosis score, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), interleukin-8 (IL-8), and malondialdehyde (MDA) increased, and antioxidant indices decreased across the ordered groups (all p < 0.0001). These cross-sectional findings support a hypothesis-generating biomarker framework linking dysbiosis, postbiotic depletion, circadian disruption, inflammation, and redox imbalance across age-related disease states.