Effects of captopril and losartan on early wound healing in hypertensive rats.
AC, B., BC, H., MLPB, S., & SO, I. (2026). Effects of captopril and losartan on early wound healing in hypertensive rats.. Acta cirurgica brasileira. https://doi.org/10.1590/acb413126
AC B, BC H, MLPB S, SO I. Effects of captopril and losartan on early wound healing in hypertensive rats.. Acta cirurgica brasileira. 2026; doi: 10.1590/acb413126
AC B, BC H, MLPB S, et al. Effects of captopril and losartan on early wound healing in hypertensive rats.[J]. Acta cirurgica brasileira. 2026. DOI: 10.1590/acb413126.
@article{ac2026,
author = {Braz AC and Hendges BC and Simões MLPB and Ioshii SO},
title = {Effects of captopril and losartan on early wound healing in hypertensive rats.},
journal = {Acta cirurgica brasileira},
year = {2026},
doi = {10.1590/acb413126},
note = {PMID: 42454826},
}
TY - JOUR AU - Braz AC AU - Hendges BC AU - Simões MLPB AU - Ioshii SO TI - Effects of captopril and losartan on early wound healing in hypertensive rats. T2 - Acta cirurgica brasileira PY - 2026 DO - 10.1590/acb413126 AN - PMID:42454826 ER -
PURPOSE: To compare the effects of captopril and losartan on inflammatory response, angiogenesis, and fibroblast activity during the early phase of wound healing in hypertensive rats. METHODS: Twenty-seven paraffin-embedded skin wound samples from hypertensive rats were analyzed: control group (n = 8), losartan-treated group (n = 9), and captopril-treated group (n = 10). Histological and immunohistochemical analyses were performed on postoperative day 4. Hematoxylin-eosin staining was used to evaluate general wound structure, and immunohistochemistry with anti-leukocyte common antigen, anti-CD34, and anti-smooth muscle actin was performed to assess inflammatory cells, angiogenesis, and fibroblast activity, respectively. RESULTS: No significant differences were observed in angiogenesis (p > 0.05) or fibroblast number (p > 0.05) between groups. However, the inflammatory reaction was significantly higher in captopril-treated (p = 0.0459) and losartan-treated (p = 0.0452) groups compared with the control group, with no significant difference between the two treated groups. CONCLUSION: Neither captopril nor losartan influenced angiogenesis or fibroblast proliferation in the early healing phase. However, both drugs increased inflammatory cell infiltration.