Phytochemical Characterization and Immunometabolic Modulation by Mangifera indica (Mahajanaka) Pulp Extract in Diabetic and Hypertensive Rat Models.
W, T., H, T., A, P., S, Y., T, T., D, K., Y, Z., & S, S. (2026). Phytochemical Characterization and Immunometabolic Modulation by Mangifera indica (Mahajanaka) Pulp Extract in Diabetic and Hypertensive Rat Models.. International journal of molecular sciences. https://doi.org/10.3390/ijms27135742
W T, H T, A P, S Y, T T, D K, et al. Phytochemical Characterization and Immunometabolic Modulation by Mangifera indica (Mahajanaka) Pulp Extract in Diabetic and Hypertensive Rat Models.. International journal of molecular sciences. 2026; doi: 10.3390/ijms27135742
W T, H T, A P, et al. Phytochemical Characterization and Immunometabolic Modulation by Mangifera indica (Mahajanaka) Pulp Extract in Diabetic and Hypertensive Rat Models.[J]. International journal of molecular sciences. 2026. DOI: 10.3390/ijms27135742.
@article{w2026,
author = {Tipsuwan W and Thananchai H and Pongjanta A and Yubo S and Taesothikul T and Kanjanapothi D and Zhong Y and Srichairatanakool S},
title = {Phytochemical Characterization and Immunometabolic Modulation by Mangifera indica (Mahajanaka) Pulp Extract in Diabetic and Hypertensive Rat Models.},
journal = {International journal of molecular sciences},
year = {2026},
doi = {10.3390/ijms27135742},
note = {PMID: 42450015},
}
TY - JOUR AU - Tipsuwan W AU - Thananchai H AU - Pongjanta A AU - Yubo S AU - Taesothikul T AU - Kanjanapothi D AU - Zhong Y AU - Srichairatanakool S TI - Phytochemical Characterization and Immunometabolic Modulation by Mangifera indica (Mahajanaka) Pulp Extract in Diabetic and Hypertensive Rat Models. T2 - International journal of molecular sciences PY - 2026 DO - 10.3390/ijms27135742 AN - PMID:42450015 ER -
Mango (Mangifera indica L.) pulp contains bioactive compounds with potential therapeutic effects against metabolic and immune-related disorders. However, the integrated effects of mango pulp extract on metabolic, cardiovascular, and immunomodulatory functions remain insufficiently characterized. Therefore, this study aimed to characterize the phytochemical composition and evaluate the activity of M. indica (Mahajanaka) pulp ethanolic extract (MPEE) in rat models. Streptozotocin (STZ)-induced diabetic rats and N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats were used to assess metabolic and cardiovascular effects, while immune function was examined through neutrophil phagocytosis, splenocyte proliferation, lymphocyte subpopulation analysis, and cytokine secretion. MPEE exhibited a rich phytochemical profile, particularly phenolic compounds, along with strong antioxidant activity (339 ± 8.9 mg gallic acid equivalent/g extract). In STZ-induced diabetic rats, MPEE at 300 mg/kg significantly reduced plasma triglyceride (36.7%) and total cholesterol (45.3%) levels compared with untreated diabetic controls, although its antihyperglycemic effect was modest (6.8%). In L-NAME-induced hypertensive rats, MPEE at 400 mg/kg produced the greatest reduction in blood pressure (42.7%) and heart rate (53.5%). Furthermore, MPEE enhanced neutrophil phagocytic activity (43%), with significant increases observed at doses of 100-400 mg/kg. These findings indicate that MPEE exerts antioxidant, hypolipidemic, antihypertensive, and innate immunostimulatory activities.