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Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients.

期刊: Circulation 日期: 2026-06-23 PMID: 42137960 浏览: 34
作者: Vega, O'Mahony, Barbour, Yu, Knöchel, Brengdahl, Hochdörfer, Bergenholm, Töppner Carlsson, Ahnmark, Underwood, Rudvik, Carter, Laru, Gutgsell, Twaddle, Garkaviy, Bogstedt, Hurt-Camejo, Miliotis, Ryaboshapkina, Hober, Hubbard, Serrano-Wu, Kaushik, Geschwindner, McCarthy, Lindén, Rosenmeier
Vega, O'Mahony, Barbour, Yu, Knöchel, Brengdahl, Hochdörfer, Bergenholm, Carlsson, T., Ahnmark, Underwood, Rudvik, Carter, Laru, Gutgsell, Twaddle, Garkaviy, Bogstedt, Hurt-Camejo, . . . Rosenmeier (2026). Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients.. Circulation.
Vega, O'Mahony, Barbour, Yu, Knöchel, Brengdahl, et al. Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients.. Circulation. 2026; PMID: 42137960
Vega, O'Mahony, Barbour, et al. Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients.[J]. Circulation. 2026.
@article{vega2026,
  author = {Vega and O'Mahony and Barbour and Yu and Knöchel and Brengdahl and Hochdörfer and Bergenholm and Töppner Carlsson and Ahnmark and Underwood and Rudvik and Carter and Laru and Gutgsell and Twaddle and Garkaviy and Bogstedt and Hurt-Camejo and Miliotis and Ryaboshapkina and Hober and Hubbard and Serrano-Wu and Kaushik and Geschwindner and McCarthy and Lindén and Rosenmeier},
  title = {Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients.},
  journal = {Circulation},
  year = {2026},
  note = {PMID: 42137960},
}
TY  - JOUR
AU  - Vega
AU  - O'Mahony
AU  - Barbour
AU  - Yu
AU  - Knöchel
AU  - Brengdahl
AU  - Hochdörfer
AU  - Bergenholm
AU  - Töppner Carlsson
AU  - Ahnmark
AU  - Underwood
AU  - Rudvik
AU  - Carter
AU  - Laru
AU  - Gutgsell
AU  - Twaddle
AU  - Garkaviy
AU  - Bogstedt
AU  - Hurt-Camejo
AU  - Miliotis
AU  - Ryaboshapkina
AU  - Hober
AU  - Hubbard
AU  - Serrano-Wu
AU  - Kaushik
AU  - Geschwindner
AU  - McCarthy
AU  - Lindén
AU  - Rosenmeier
TI  - Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients.
T2  - Circulation
PY  - 2026
AN  - PMID:42137960
ER  - 

摘要

Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) is an effective therapy for reducing low-density lipoprotein (LDL) cholesterol (LDL-C) in adults with hyperlipidemia, including heterozygous familial hypercholesterolemia, thereby lowering cardiovascular risk. Current PCSK9 inhibitors are injectable therapies; no oral small-molecule PCSK9 inhibitor has yet been approved.

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