Vega, O'Mahony, Barbour, Yu, Knöchel, Brengdahl, Hochdörfer, Bergenholm, Carlsson, T., Ahnmark, Underwood, Rudvik, Carter, Laru, Gutgsell, Twaddle, Garkaviy, Bogstedt, Hurt-Camejo, . . . Rosenmeier (2026). Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients.. Circulation.
Vega, O'Mahony, Barbour, Yu, Knöchel, Brengdahl, et al. Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients.. Circulation. 2026; PMID: 42137960
Vega, O'Mahony, Barbour, et al. Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients.[J]. Circulation. 2026.
@article{vega2026,
author = {Vega and O'Mahony and Barbour and Yu and Knöchel and Brengdahl and Hochdörfer and Bergenholm and Töppner Carlsson and Ahnmark and Underwood and Rudvik and Carter and Laru and Gutgsell and Twaddle and Garkaviy and Bogstedt and Hurt-Camejo and Miliotis and Ryaboshapkina and Hober and Hubbard and Serrano-Wu and Kaushik and Geschwindner and McCarthy and Lindén and Rosenmeier},
title = {Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients.},
journal = {Circulation},
year = {2026},
note = {PMID: 42137960},
}
TY - JOUR AU - Vega AU - O'Mahony AU - Barbour AU - Yu AU - Knöchel AU - Brengdahl AU - Hochdörfer AU - Bergenholm AU - Töppner Carlsson AU - Ahnmark AU - Underwood AU - Rudvik AU - Carter AU - Laru AU - Gutgsell AU - Twaddle AU - Garkaviy AU - Bogstedt AU - Hurt-Camejo AU - Miliotis AU - Ryaboshapkina AU - Hober AU - Hubbard AU - Serrano-Wu AU - Kaushik AU - Geschwindner AU - McCarthy AU - Lindén AU - Rosenmeier TI - Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients. T2 - Circulation PY - 2026 AN - PMID:42137960 ER -
Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) is an effective therapy for reducing low-density lipoprotein (LDL) cholesterol (LDL-C) in adults with hyperlipidemia, including heterozygous familial hypercholesterolemia, thereby lowering cardiovascular risk. Current PCSK9 inhibitors are injectable therapies; no oral small-molecule PCSK9 inhibitor has yet been approved.