Multi-Target Cardioprotective Potential of Garcinia indica Choisy in Olanzapine-Induced Cardiometabolic Dysregulation: Evidence From Computational and Experimental Insights in H9c2(2-1) Cells.
FA, B., SV, K., A, K., VS, P., R, C., SS, G., VV, B., HR, D., NA, K., & S, R. (2026). Multi-Target Cardioprotective Potential of Garcinia indica Choisy in Olanzapine-Induced Cardiometabolic Dysregulation: Evidence From Computational and Experimental Insights in H9c2(2-1) Cells.. Chemistry & biodiversity. https://doi.org/10.1002/cbdv.202503806
FA B, SV K, A K, VS P, R C, SS G, et al. Multi-Target Cardioprotective Potential of Garcinia indica Choisy in Olanzapine-Induced Cardiometabolic Dysregulation: Evidence From Computational and Experimental Insights in H9c2(2-1) Cells.. Chemistry & biodiversity. 2026; doi: 10.1002/cbdv.202503806
FA B, SV K, A K, et al. Multi-Target Cardioprotective Potential of Garcinia indica Choisy in Olanzapine-Induced Cardiometabolic Dysregulation: Evidence From Computational and Experimental Insights in H9c2(2-1) Cells.[J]. Chemistry & biodiversity. 2026. DOI: 10.1002/cbdv.202503806.
@article{fa2026,
author = {Beerwala FA and Kolambkar SV and Karikazi A and Patil VS and Charla R and Gujarathi SS and Bhandare VV and Darasaguppe HR and Khatib NA and Roy S},
title = {Multi-Target Cardioprotective Potential of Garcinia indica Choisy in Olanzapine-Induced Cardiometabolic Dysregulation: Evidence From Computational and Experimental Insights in H9c2(2-1) Cells.},
journal = {Chemistry & biodiversity},
year = {2026},
doi = {10.1002/cbdv.202503806},
note = {PMID: 42460687},
}
TY - JOUR AU - Beerwala FA AU - Kolambkar SV AU - Karikazi A AU - Patil VS AU - Charla R AU - Gujarathi SS AU - Bhandare VV AU - Darasaguppe HR AU - Khatib NA AU - Roy S TI - Multi-Target Cardioprotective Potential of Garcinia indica Choisy in Olanzapine-Induced Cardiometabolic Dysregulation: Evidence From Computational and Experimental Insights in H9c2(2-1) Cells. T2 - Chemistry & biodiversity PY - 2026 DO - 10.1002/cbdv.202503806 AN - PMID:42460687 ER -
Olanzapine (OLZ), a commonly prescribed atypical antipsychotic, is strongly linked to cardiometabolic disorders (CMDs) such as obesity, insulin resistance, dyslipidemia, and cardiac dysfunction. Garcinia indica Choisy (kokum), a nutrient-rich medicinal fruit with antioxidant, anti-obesity, antidiabetic, and cardioprotective properties, has not yet been investigated for its potential to counter OLZ-induced CMD(s). This study examined the protective effects and underlying mechanisms of G. indica hydroalcoholic extract (GIE) against OLZ-induced cardiometabolic alterations using in vitro and computational approaches. GIE significantly reduced OLZ-induced cytotoxicity in H9c2(2-1) cardiomyocytes by lowering lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), and nitric oxide (NO) levels, while enhancing glucose utilization. Gene expression analysis showed downregulation of IL6, BAX, CASP3, and CAMK2B, alongside upregulation of BCL2, indicating anti-inflammatory and anti-apoptotic modulation. Network pharmacology and in silico analyses identified thirteen phytocompounds targeting 35 CMD-related proteins, with gambogic acid- RAGE and amentoflavone- CALM1 interactions demonstrating the strongest binding affinities, supported by docking and molecular dynamics simulations. Overall, GIE exhibits multi-target regulatory effects on oxidative, inflammatory, and metabolic pathways, suggesting its therapeutic potential in mitigating OLZ-induced cardiometabolic disturbances. The current findings indicate promising mechanistic potential of GIE against OLZ- induced cardiometabolic alterations, warranting further validation through in vivo and clinical studies.