Assessment of markers of primary aldosteronism in systemic sclerosis and their relationships with renal and cardiovascular outcomes.
A, C., S, S., S, E., B, D., R, V., S, D., E, H., C, D., D, L., & J, Y. (2026). Assessment of markers of primary aldosteronism in systemic sclerosis and their relationships with renal and cardiovascular outcomes.. RMD open. https://doi.org/10.1136/rmdopen-2026-006930
A C, S S, S E, B D, R V, S D, et al. Assessment of markers of primary aldosteronism in systemic sclerosis and their relationships with renal and cardiovascular outcomes.. RMD open. 2026; doi: 10.1136/rmdopen-2026-006930
A C, S S, S E, et al. Assessment of markers of primary aldosteronism in systemic sclerosis and their relationships with renal and cardiovascular outcomes.[J]. RMD open. 2026. DOI: 10.1136/rmdopen-2026-006930.
@article{a2026,
author = {Collet A and Sanges S and Espiard S and Djobo B and Vankemmel R and Dubucquoi S and Hachulla E and Douillard C and Launay D and Yang J},
title = {Assessment of markers of primary aldosteronism in systemic sclerosis and their relationships with renal and cardiovascular outcomes.},
journal = {RMD open},
year = {2026},
doi = {10.1136/rmdopen-2026-006930},
note = {PMID: 42457209},
}
TY - JOUR AU - Collet A AU - Sanges S AU - Espiard S AU - Djobo B AU - Vankemmel R AU - Dubucquoi S AU - Hachulla E AU - Douillard C AU - Launay D AU - Yang J TI - Assessment of markers of primary aldosteronism in systemic sclerosis and their relationships with renal and cardiovascular outcomes. T2 - RMD open PY - 2026 DO - 10.1136/rmdopen-2026-006930 AN - PMID:42457209 ER -
BACKGROUND: Whether primary aldosteronism (PA), the most common endocrine cause of hypertension (HTN), contributes to HTN and cardiovascular disease burden in systemic sclerosis (SSc) has never been explored. We aimed to assess the prevalence and management of HTN, prevalence of positive PA screening test results and the associations between markers of PA with HTN and SSc-related outcomes in SSc. METHODS: Data from adult SSc patients and normotensive healthy controls (HC) were analysed in this single-centre study. HTN was defined as blood pressures ≥140/90 mm Hg on two visits or as documented in medical records. PA screening was performed using the aldosterone:renin ratio (ARR). Associations between biomarkers of PA (renin, aldosterone, ARR, hybrid steroid 18-hydroxycortisol (18OHF)) with HTN and SSc-related outcomes were assessed using multivariable regression modelling. RESULTS: Data from 112 SSc patients (median (IQR) age 60 (49, 69) years, 79% female) and 48 HC (median (IQR) age 42.5 (31, 57) years, 52% female) were analysed. At baseline, 41 SSc patients (37%) had HTN, increasing to 52% of the cohort at the last follow-up visit (median follow-up 5.1 years). The prevalence of positive baseline ARR in SSc was 8% (9/112), corresponding to 12% (5/41) in the hypertensive subset. No associations were observed between biomarkers of PA and SSc-related renal and cardiovascular outcomes or HTN at last follow-up visit. CONCLUSIONS: HTN was common in this SSc cohort, and prevalence of positive PA screening test was estimated at 12% among hypertensive SSc patients, supporting consideration of PA screening in this population.