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Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Mitophagy.

期刊: Circulation research 日期: 2026-06-19 PMID: 42137941 浏览: 39
作者: Atici, Jena, Carvalho, Ross, Aubuchon, Lane, Gomez, Lee, Fishbein, Azer, Mesquita, Chen, Crother, Arditi, Noval Rivas
Atici, Jena, Carvalho, Ross, Aubuchon, Lane, Gomez, Lee, Fishbein, Azer, Mesquita, Chen, Crother, Arditi, & Rivas, N. (2026). Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Mitophagy.. Circulation research.
Atici, Jena, Carvalho, Ross, Aubuchon, Lane, et al. Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Mitophagy.. Circulation research. 2026; PMID: 42137941
Atici, Jena, Carvalho, et al. Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Mitophagy.[J]. Circulation research. 2026.
@article{atici2026,
  author = {Atici and Jena and Carvalho and Ross and Aubuchon and Lane and Gomez and Lee and Fishbein and Azer and Mesquita and Chen and Crother and Arditi and Noval Rivas},
  title = {Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Mitophagy.},
  journal = {Circulation research},
  year = {2026},
  note = {PMID: 42137941},
}
TY  - JOUR
AU  - Atici
AU  - Jena
AU  - Carvalho
AU  - Ross
AU  - Aubuchon
AU  - Lane
AU  - Gomez
AU  - Lee
AU  - Fishbein
AU  - Azer
AU  - Mesquita
AU  - Chen
AU  - Crother
AU  - Arditi
AU  - Noval Rivas
TI  - Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Mitophagy.
T2  - Circulation research
PY  - 2026
AN  - PMID:42137941
ER  - 

摘要

SIRT1 (sirtuin 1), a nicotinamide adenine dinucleotide-dependent protein deacetylase, regulates cardiovascular inflammation by modulating cellular stress, inhibiting NLRP3 (NLR family, pyrin domain-containing 3) activation, and promoting the clearance of damaged mitochondria. However, its precise role in the pathogenesis of Kawasaki disease, a pediatric systemic vasculitis that causes coronary artery aneurysms in children, remains unclear.

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