Jadam, Abusafia, Sultana, Keen, Gaballa, Ospina, Rutkowski, Xu, Popovic, Wierup, Thamilarasan, Smedira, & Desai (2026). Long-term outcomes of obstructive hypertrophic cardiomyopathy undergoing surgical myectomy: Impact of symptom severity at presentation.. Cardiovascular research.
Jadam, Abusafia, Sultana, Keen, Gaballa, Ospina, et al. Long-term outcomes of obstructive hypertrophic cardiomyopathy undergoing surgical myectomy: Impact of symptom severity at presentation.. Cardiovascular research. 2026; PMID: 42140669
Jadam, Abusafia, Sultana, et al. Long-term outcomes of obstructive hypertrophic cardiomyopathy undergoing surgical myectomy: Impact of symptom severity at presentation.[J]. Cardiovascular research. 2026.
@article{jadam2026,
author = {Jadam and Abusafia and Sultana and Keen and Gaballa and Ospina and Rutkowski and Xu and Popovic and Wierup and Thamilarasan and Smedira and Desai},
title = {Long-term outcomes of obstructive hypertrophic cardiomyopathy undergoing surgical myectomy: Impact of symptom severity at presentation.},
journal = {Cardiovascular research},
year = {2026},
note = {PMID: 42140669},
}
TY - JOUR AU - Jadam AU - Abusafia AU - Sultana AU - Keen AU - Gaballa AU - Ospina AU - Rutkowski AU - Xu AU - Popovic AU - Wierup AU - Thamilarasan AU - Smedira AU - Desai TI - Long-term outcomes of obstructive hypertrophic cardiomyopathy undergoing surgical myectomy: Impact of symptom severity at presentation. T2 - Cardiovascular research PY - 2026 AN - PMID:42140669 ER -
Surgical myectomy (SM), performed to relieve dynamic left ventricular outflow tract obstruction (LVOTO) in symptomatic obstructive hypertrophic cardiomyopathy (oHCM) patients provides improved quality of life and symptoms and excellent long-term survival. Guidelines recommend SM in symptomatic oHCM patients refractory to optimal medical therapy. We sought to assess whether SM in patients with fewer symptoms at initial referral is associated with improved long-term outcomes in oHCM. Baseline symptom burden at the time of referral emerged as a powerful prognostic discriminator among 3,546 HCM patients undergoing SM. Our findings suggest that earlier surgical referral before advanced decompensation may be associated with more favorable long-term outcomes. Women were more likely to present with advanced symptoms and had higher adjusted risk. These results underscore the need to determine whether a proactive therapeutic strategy, including an earlier intervention, can modify long-term survival in oHCM.