Association between triglyceride glucose-body mass index and clinical outcomes after septal myectomy.
C, S., X, Z., J, C., X, H., Q, Y., & S, W. (2026). Association between triglyceride glucose-body mass index and clinical outcomes after septal myectomy.. Frontiers in endocrinology. https://doi.org/10.3389/fendo.2026.1855510
C S, X Z, J C, X H, Q Y, S W. Association between triglyceride glucose-body mass index and clinical outcomes after septal myectomy.. Frontiers in endocrinology. 2026; doi: 10.3389/fendo.2026.1855510
C S, X Z, J C, et al. Association between triglyceride glucose-body mass index and clinical outcomes after septal myectomy.[J]. Frontiers in endocrinology. 2026. DOI: 10.3389/fendo.2026.1855510.
@article{c2026,
author = {Song C and Zheng X and Cui J and Huang X and Yang Q and Wang S},
title = {Association between triglyceride glucose-body mass index and clinical outcomes after septal myectomy.},
journal = {Frontiers in endocrinology},
year = {2026},
doi = {10.3389/fendo.2026.1855510},
note = {PMID: 42597162},
}
TY - JOUR AU - Song C AU - Zheng X AU - Cui J AU - Huang X AU - Yang Q AU - Wang S TI - Association between triglyceride glucose-body mass index and clinical outcomes after septal myectomy. T2 - Frontiers in endocrinology PY - 2026 DO - 10.3389/fendo.2026.1855510 AN - PMID:42597162 ER -
AIMS: This study examined the association between triglyceride glucose-body mass index (TyG-BMI) and clinical outcomes in patients with hypertrophic obstructive cardiomyopathy (HOCM) undergoing septal myectomy. METHODS: This retrospective cohort study was conducted at Fuwai Hospital, including 1,302 patients with HOCM who underwent septal myectomy. According to the tertile distribution of TyG-BMI, the participants were classified into three groups (T1-T3). The primary endpoint consisted of heart failure hospitalization or all-cause death. RESULTS: The mean age of the participants was 49.2 ± 11.8 years, of whom 61% (791) were men. During a median follow-up of 4.3 (3.1-6.2) years, the cumulative incidences of primary endpoint and all-cause death differed significantly across the three groups on the Kaplan-Meier analysis (log-rank P < 0.05). Cox analysis showed that patients in group T3 exhibited the greatest incidence rates of primary endpoint (adjusted hazard ratio (HR) = 2.00, 95% confidence interval (CI) 1.16-3.44, P = 0.012) as well as the highest risk of all-cause death (adjusted HR = 3.39, 95% CI 1.34-8.58, P = 0.010) compared to those in group T1. When treated as a continuous variable, TyG-BMI remained significantly linked to an elevated risk of primary endpoint (adjusted HR = 1.007, 95% CI 1.002-1.012, P = 0.009) and increased all-cause death (adjusted HR = 1.013, 95% CI 1.006-1.021, P = 0.001). CONCLUSIONS: Higher TyG-BMI was associated with an increased risk of adverse long-term outcomes after septal myectomy in patients with HOCM.