Han, Liu, Zhou, Liu, Guo, Hu, Gao, & Zeng (2026). Longitudinal associations of cumulative and repeated-measure patterns of insulin resistance surrogate indices with biological age acceleration and incident cardiovascular disease across cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from CHARLS 2011-2020.. Cardiovascular diabetology.
Han, Liu, Zhou, Liu, Guo, Hu, et al. Longitudinal associations of cumulative and repeated-measure patterns of insulin resistance surrogate indices with biological age acceleration and incident cardiovascular disease across cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from CHARLS 2011-2020.. Cardiovascular diabetology. 2026; PMID: 42143308
Han, Liu, Zhou, et al. Longitudinal associations of cumulative and repeated-measure patterns of insulin resistance surrogate indices with biological age acceleration and incident cardiovascular disease across cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from CHARLS 2011-2020.[J]. Cardiovascular diabetology. 2026.
@article{han2026,
author = {Han and Liu and Zhou and Liu and Guo and Hu and Gao and Zeng},
title = {Longitudinal associations of cumulative and repeated-measure patterns of insulin resistance surrogate indices with biological age acceleration and incident cardiovascular disease across cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from CHARLS 2011-2020.},
journal = {Cardiovascular diabetology},
year = {2026},
note = {PMID: 42143308},
}
TY - JOUR AU - Han AU - Liu AU - Zhou AU - Liu AU - Guo AU - Hu AU - Gao AU - Zeng TI - Longitudinal associations of cumulative and repeated-measure patterns of insulin resistance surrogate indices with biological age acceleration and incident cardiovascular disease across cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from CHARLS 2011-2020. T2 - Cardiovascular diabetology PY - 2026 AN - PMID:42143308 ER -
Cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3 represent a critical window for preventing progression to overt cardiovascular disease (CVD). Insulin resistance (IR) is central to CKM pathophysiology, yet the comparative utility of longitudinal IR patterns (cumulative burden and longitudinal pattern groups) across multiple surrogates, and the mediating role of biological ageing, remain unexamined in this preclinical population.