Impact of Microaxial Flow Pump on Coronary Flow Dynamics in Normal Hearts: An Experimental Evaluation.
T, I., K, S., K, O., T, N., H, M., M, O., S, Y., K, S., H, M., & N, H. (2026). Impact of Microaxial Flow Pump on Coronary Flow Dynamics in Normal Hearts: An Experimental Evaluation.. Journal of cardiovascular translational research. https://doi.org/10.1007/s12265-026-10818-z
T I, K S, K O, T N, H M, M O, et al. Impact of Microaxial Flow Pump on Coronary Flow Dynamics in Normal Hearts: An Experimental Evaluation.. Journal of cardiovascular translational research. 2026; doi: 10.1007/s12265-026-10818-z
T I, K S, K O, et al. Impact of Microaxial Flow Pump on Coronary Flow Dynamics in Normal Hearts: An Experimental Evaluation.[J]. Journal of cardiovascular translational research. 2026. DOI: 10.1007/s12265-026-10818-z.
@article{t2026,
author = {Ito T and Saku K and Ohba K and Nishikawa T and Matsushita H and Otake M and Yokota S and Sato K and Morita H and Hiraki N},
title = {Impact of Microaxial Flow Pump on Coronary Flow Dynamics in Normal Hearts: An Experimental Evaluation.},
journal = {Journal of cardiovascular translational research},
year = {2026},
doi = {10.1007/s12265-026-10818-z},
note = {PMID: 42474903},
}
TY - JOUR AU - Ito T AU - Saku K AU - Ohba K AU - Nishikawa T AU - Matsushita H AU - Otake M AU - Yokota S AU - Sato K AU - Morita H AU - Hiraki N TI - Impact of Microaxial Flow Pump on Coronary Flow Dynamics in Normal Hearts: An Experimental Evaluation. T2 - Journal of cardiovascular translational research PY - 2026 DO - 10.1007/s12265-026-10818-z AN - PMID:42474903 ER -
The effects of microaxial flow pump (mAFP) support on coronary flow (CF) are well characterized in failing hearts, but its impact on CF in normal hearts under different levels of left ventricular (LV) unloading remains unclear. Seven anesthetized Saanen goats underwent left thoracotomy, and an Impella 5.5 device was implanted via the left common carotid artery and operated at incremental support levels: Control (P1-2), Partial (P4-6), and Total (P7-9). Coronary perfusion pressure (CPP), coronary vascular resistance (CVR), myocardial oxygen consumption (MVO₂), and diastolic LV wall stress were calculated at each level. With increasing mAFP support, CPP increased whereas CF decreased by 32.1% from Control to Total support (69.6 ± 19.8 vs. 48.4 ± 21.1 mL/min), and CVR increased 260% (0.5 ± 0.2 vs. 1.8 ± 1.3 mmHg·min/mL). In normal hearts, mAFP elevates CPP but paradoxically reduces CF due to increased CVR associated with LV unloading.