Gastrodin mitigates cisplatin-induced cardiotoxicity in Swiss albino mice by restoring redox homeostasis and modulating the p62-Keap1-Nrf2 Axis.
A, A., E, Q., Y, B., AE, H., O, G., SAR, S., & AAA, A. (2026). Gastrodin mitigates cisplatin-induced cardiotoxicity in Swiss albino mice by restoring redox homeostasis and modulating the p62-Keap1-Nrf2 Axis.. Molecular biology reports. https://doi.org/10.1007/s11033-026-12277-w
A A, E Q, Y B, AE H, O G, SAR S, et al. Gastrodin mitigates cisplatin-induced cardiotoxicity in Swiss albino mice by restoring redox homeostasis and modulating the p62-Keap1-Nrf2 Axis.. Molecular biology reports. 2026; doi: 10.1007/s11033-026-12277-w
A A, E Q, Y B, et al. Gastrodin mitigates cisplatin-induced cardiotoxicity in Swiss albino mice by restoring redox homeostasis and modulating the p62-Keap1-Nrf2 Axis.[J]. Molecular biology reports. 2026. DOI: 10.1007/s11033-026-12277-w.
@article{a2026,
author = {Alqudah A and Qnais E and Bsieso Y and Hamdallah AE and Gammoh O and Shilbayeh SAR and Aljabali AAA},
title = {Gastrodin mitigates cisplatin-induced cardiotoxicity in Swiss albino mice by restoring redox homeostasis and modulating the p62-Keap1-Nrf2 Axis.},
journal = {Molecular biology reports},
year = {2026},
doi = {10.1007/s11033-026-12277-w},
note = {PMID: 42474781},
}
TY - JOUR AU - Alqudah A AU - Qnais E AU - Bsieso Y AU - Hamdallah AE AU - Gammoh O AU - Shilbayeh SAR AU - Aljabali AAA TI - Gastrodin mitigates cisplatin-induced cardiotoxicity in Swiss albino mice by restoring redox homeostasis and modulating the p62-Keap1-Nrf2 Axis. T2 - Molecular biology reports PY - 2026 DO - 10.1007/s11033-026-12277-w AN - PMID:42474781 ER -
BACKGROUND: Cisplatin (CP) chemotherapy can elicit clinically meaningful cardiac injury, and the additional use of effective cardioprotective agents is a pressing need. This study investigated the protective effects and mechanisms of gastrodin against CP-induced cardiotoxicity, through redox-, inflammatory-, apoptotic-, and Nrf2-axis mechanisms. METHODS: Adult male Swiss albino mice received CP (5 mg/kg, i.p., Days 3 and 6) with or without oral gastrodin (50 or 100 mg/kg/day) for 7 days. Outcomes included cardiac histology, serum/tissue injury markers, myocardial ATP, oxidative stress indices, cytokines, and qRT-PCR for apoptosis- and Nrf2-pathway genes. RESULTS: CP produced marked myocardial injury, increasing the histological injury score (p < 0.001), and elevated serum cTnI (p < 0.001). CP depleted myocardial ATP (p < 0.001) and increased lipid peroxidation, as reflected by elevated MDA (p < 0.001). These changes were accompanied by increased TNF-α and IL-6 (p < 0.001). Gastrodin 100 mg/kg significantly attenuated these alterations, reducing the histological injury score, serum cTnI, restoring ATP, and lowering MDA (p < 0.05-0.001 vs. CP). Gastrodin also reduced TNF-α and IL-6 and shifted gene expression toward cytoprotection. CONCLUSION: Gastrodin may have a protective activity against CP cardiotoxicity, primarily by restoring redox balance/energy status, suppressing inflammation and apoptosis, and modulating p62-Keap1-Nrf2 related gene expression.