Xie, Min, Wang, Zou, Zheng, Chen, Shao, Yang, Sun, Xiong, Gu, Shi, Xu, Xu, Yuan, Zhao, Tao, Wang, Liu, . . . Chen (2026). Cardiac α4β2 nicotinic receptors as a therapeutic target for fatal ventricular arrhythmias.. European heart journal.
Xie, Min, Wang, Zou, Zheng, Chen, et al. Cardiac α4β2 nicotinic receptors as a therapeutic target for fatal ventricular arrhythmias.. European heart journal. 2026; PMID: 42149943
Xie, Min, Wang, et al. Cardiac α4β2 nicotinic receptors as a therapeutic target for fatal ventricular arrhythmias.[J]. European heart journal. 2026.
@article{xie2026,
author = {Xie and Min and Wang and Zou and Zheng and Chen and Shao and Yang and Sun and Xiong and Gu and Shi and Xu and Xu and Yuan and Zhao and Tao and Wang and Liu and Dong and Hao and Chen},
title = {Cardiac α4β2 nicotinic receptors as a therapeutic target for fatal ventricular arrhythmias.},
journal = {European heart journal},
year = {2026},
note = {PMID: 42149943},
}
TY - JOUR AU - Xie AU - Min AU - Wang AU - Zou AU - Zheng AU - Chen AU - Shao AU - Yang AU - Sun AU - Xiong AU - Gu AU - Shi AU - Xu AU - Xu AU - Yuan AU - Zhao AU - Tao AU - Wang AU - Liu AU - Dong AU - Hao AU - Chen TI - Cardiac α4β2 nicotinic receptors as a therapeutic target for fatal ventricular arrhythmias. T2 - European heart journal PY - 2026 AN - PMID:42149943 ER -
Fatal ventricular tachyarrhythmias (FVTs) are a major cause of sudden cardiac death globally. Despite their clinical importance, current antiarrhythmic therapies remain constrained by limited efficacy and proarrhythmic risks. Although endogenous cardiac cholinergic signalling contributes to electrophysiological regulation, the therapeutic potential of targeting ventricular α4β2 nicotinic acetylcholine receptors (nAChRs), a pivotal component of this system, for FVT treatment remains to be elucidated.