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Cardiac α4β2 nicotinic receptors as a therapeutic target for fatal ventricular arrhythmias.

期刊: European heart journal 日期: 2026-05-18 PMID: 42149943 浏览: 44
作者: Xie, Min, Wang, Zou, Zheng, Chen, Shao, Yang, Sun, Xiong, Gu, Shi, Xu, Xu, Yuan, Zhao, Tao, Wang, Liu, Dong, Hao, Chen
Xie, Min, Wang, Zou, Zheng, Chen, Shao, Yang, Sun, Xiong, Gu, Shi, Xu, Xu, Yuan, Zhao, Tao, Wang, Liu, . . . Chen (2026). Cardiac α4β2 nicotinic receptors as a therapeutic target for fatal ventricular arrhythmias.. European heart journal.
Xie, Min, Wang, Zou, Zheng, Chen, et al. Cardiac α4β2 nicotinic receptors as a therapeutic target for fatal ventricular arrhythmias.. European heart journal. 2026; PMID: 42149943
Xie, Min, Wang, et al. Cardiac α4β2 nicotinic receptors as a therapeutic target for fatal ventricular arrhythmias.[J]. European heart journal. 2026.
@article{xie2026,
  author = {Xie and Min and Wang and Zou and Zheng and Chen and Shao and Yang and Sun and Xiong and Gu and Shi and Xu and Xu and Yuan and Zhao and Tao and Wang and Liu and Dong and Hao and Chen},
  title = {Cardiac α4β2 nicotinic receptors as a therapeutic target for fatal ventricular arrhythmias.},
  journal = {European heart journal},
  year = {2026},
  note = {PMID: 42149943},
}
TY  - JOUR
AU  - Xie
AU  - Min
AU  - Wang
AU  - Zou
AU  - Zheng
AU  - Chen
AU  - Shao
AU  - Yang
AU  - Sun
AU  - Xiong
AU  - Gu
AU  - Shi
AU  - Xu
AU  - Xu
AU  - Yuan
AU  - Zhao
AU  - Tao
AU  - Wang
AU  - Liu
AU  - Dong
AU  - Hao
AU  - Chen
TI  - Cardiac α4β2 nicotinic receptors as a therapeutic target for fatal ventricular arrhythmias.
T2  - European heart journal
PY  - 2026
AN  - PMID:42149943
ER  - 

摘要

Fatal ventricular tachyarrhythmias (FVTs) are a major cause of sudden cardiac death globally. Despite their clinical importance, current antiarrhythmic therapies remain constrained by limited efficacy and proarrhythmic risks. Although endogenous cardiac cholinergic signalling contributes to electrophysiological regulation, the therapeutic potential of targeting ventricular α4β2 nicotinic acetylcholine receptors (nAChRs), a pivotal component of this system, for FVT treatment remains to be elucidated.

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