Rios, Montezano, Camargo, Lopes, García-Redondo, Aranday-Cortes, Briones, McLauchlan, & Touyz (2026). Spike 1 protein of SARS-CoV-2 induces endothelial inflammation and vascular dysfunction through interferon ISG15-dependent mechanisms.. Cardiovascular research.
Rios, Montezano, Camargo, Lopes, García-Redondo, Aranday-Cortes, et al. Spike 1 protein of SARS-CoV-2 induces endothelial inflammation and vascular dysfunction through interferon ISG15-dependent mechanisms.. Cardiovascular research. 2026; PMID: 42150851
Rios, Montezano, Camargo, et al. Spike 1 protein of SARS-CoV-2 induces endothelial inflammation and vascular dysfunction through interferon ISG15-dependent mechanisms.[J]. Cardiovascular research. 2026.
@article{rios2026,
author = {Rios and Montezano and Camargo and Lopes and García-Redondo and Aranday-Cortes and Briones and McLauchlan and Touyz},
title = {Spike 1 protein of SARS-CoV-2 induces endothelial inflammation and vascular dysfunction through interferon ISG15-dependent mechanisms.},
journal = {Cardiovascular research},
year = {2026},
note = {PMID: 42150851},
}
TY - JOUR AU - Rios AU - Montezano AU - Camargo AU - Lopes AU - García-Redondo AU - Aranday-Cortes AU - Briones AU - McLauchlan AU - Touyz TI - Spike 1 protein of SARS-CoV-2 induces endothelial inflammation and vascular dysfunction through interferon ISG15-dependent mechanisms. T2 - Cardiovascular research PY - 2026 AN - PMID:42150851 ER -
Interferon (IFN) alpha (IFNα) and lambda3 (IFNλ3) constitute first line responses of immunity against SARS-CoV-2 infection by increasing interferon-stimulated genes (ISGs). Prolonged IFN production may exacerbate inflammation, contributing to endotheliitis and vascular dysfunction in COVID-19. We investigated whether spike protein S1 (SP1) of SARS-CoV-2 via IFN influences inflammation in human vascular and lymphatic endothelial cells (EC) and whether these processes contribute to vascular dysfunction in the context of hypertension. We focused on ISG15, a crucial immune protein that is also implicated in hypertension-associated vascular injury.