Calcium-channel blockade-mediated blood pressure-lowering and vasorelaxant effects of Brassica oleracea.
M, H., MA, C., M, A., & MS, H. (2026). Calcium-channel blockade-mediated blood pressure-lowering and vasorelaxant effects of Brassica oleracea.. Pakistan journal of pharmaceutical sciences. https://doi.org/10.36721/PJPS.2026.39.10.294.1
M H, MA C, M A, MS H. Calcium-channel blockade-mediated blood pressure-lowering and vasorelaxant effects of Brassica oleracea.. Pakistan journal of pharmaceutical sciences. 2026; doi: 10.36721/PJPS.2026.39.10.294.1
M H, MA C, M A, et al. Calcium-channel blockade-mediated blood pressure-lowering and vasorelaxant effects of Brassica oleracea.[J]. Pakistan journal of pharmaceutical sciences. 2026. DOI: 10.36721/PJPS.2026.39.10.294.1.
@article{m2026,
author = {Haroon M and Chaudhry MA and Ambreen M and Haider MS},
title = {Calcium-channel blockade-mediated blood pressure-lowering and vasorelaxant effects of Brassica oleracea.},
journal = {Pakistan journal of pharmaceutical sciences},
year = {2026},
doi = {10.36721/PJPS.2026.39.10.294.1},
note = {PMID: 42489302},
}
TY - JOUR AU - Haroon M AU - Chaudhry MA AU - Ambreen M AU - Haider MS TI - Calcium-channel blockade-mediated blood pressure-lowering and vasorelaxant effects of Brassica oleracea. T2 - Pakistan journal of pharmaceutical sciences PY - 2026 DO - 10.36721/PJPS.2026.39.10.294.1 AN - PMID:42489302 ER -
BACKGROUND: Brassica oleracea L. (Brassicaceae), commonly known as cabbage, is usually used for dietary purposes and is also known for many medicinal uses, including blood pressure. OBJECTIVES: The current research study aimed to authenticate the traditional claims of B. oleracea L. for hypertension on a scientific basis using in vivo and in vitro pharmacological techniques. METHODS: Crude extract of B. oleracea L. was evaluated for its hypotensive and vasorelaxant effects in normotensive anesthetized wistar rats using an invasive blood pressure-measuring technique and isolated rat thoracic aorta, respectively. RESULTS: Normotensive anaesthetized rats used in experiments showed a gradual decrease in blood pressure parameters and heart rate when treated with Bo.Cr (0.1-100 mg/kg) comparable to verapamil (0.01-30 mg/kg). Whereas, in isolated aortic tissue, Bo.Cr (0.01-3 mg/ml) exhibited complete relaxation on high K+ [80 mM] and phenylephrine (1 µM)-mediated contractions. Crude extract at doses of 0.3 and 1 mg/ml also showed a reduction in response to Ca2+ concentration-response curves. CONCLUSION: Results indicate calcium channel-blocking activity, a possible cause of the blood pressure-lowering and vasodilator effects of B. oleracea.