Myocardial microvascular patterns in histological sections from patients with and without type 2 diabetes.
J, Š., A, P., V, M., & T, K. (2026). Myocardial microvascular patterns in histological sections from patients with and without type 2 diabetes.. PloS one. https://doi.org/10.1371/journal.pone.0354451
J Š, A P, V M, T K. Myocardial microvascular patterns in histological sections from patients with and without type 2 diabetes.. PloS one. 2026; doi: 10.1371/journal.pone.0354451
J Š, A P, V M, et al. Myocardial microvascular patterns in histological sections from patients with and without type 2 diabetes.[J]. PloS one. 2026. DOI: 10.1371/journal.pone.0354451.
@article{j2026,
author = {Šrámek J and Pierzynová A and Melenovský V and Kučera T},
title = {Myocardial microvascular patterns in histological sections from patients with and without type 2 diabetes.},
journal = {PloS one},
year = {2026},
doi = {10.1371/journal.pone.0354451},
note = {PMID: 42490663},
}
TY - JOUR AU - Šrámek J AU - Pierzynová A AU - Melenovský V AU - Kučera T TI - Myocardial microvascular patterns in histological sections from patients with and without type 2 diabetes. T2 - PloS one PY - 2026 DO - 10.1371/journal.pone.0354451 AN - PMID:42490663 ER -
Type 2 diabetes is associated with small vessels dysfunction. This study assessed whether type 2 diabetes is associated with changes in the myocardial capillary pattern in two-dimensional histological sections as an indirect proxy for the three-dimensional network in the myocardium. We used myocardial samples from the left and right ventricles harvested during cardiac surgery (N = 53; 44 without and 9 with type 2 diabetes). We prepared histological sections with CD34-immunostained endothelium. We used cross-sections through the small vessels as points for two methods of point-pattern analysis: Voronoi-based analysis and fractal-based analysis. We were unable to detect differences in the microvascular pattern on myocardial sections of participants with and without type 2 diabetes.