Serum Uric Acid Changes in Relation to Nighttime Blood Pressure Dipping Status in Patients on Antihypertensive Therapy.
D, Z., QF, H., Y, L., & JG, W. (2026). Serum Uric Acid Changes in Relation to Nighttime Blood Pressure Dipping Status in Patients on Antihypertensive Therapy.. Journal of clinical hypertension (Greenwich, Conn.). https://doi.org/10.1111/jch.70324
D Z, QF H, Y L, JG W. Serum Uric Acid Changes in Relation to Nighttime Blood Pressure Dipping Status in Patients on Antihypertensive Therapy.. Journal of clinical hypertension (Greenwich, Conn.). 2026; doi: 10.1111/jch.70324
D Z, QF H, Y L, et al. Serum Uric Acid Changes in Relation to Nighttime Blood Pressure Dipping Status in Patients on Antihypertensive Therapy.[J]. Journal of clinical hypertension (Greenwich, Conn.). 2026. DOI: 10.1111/jch.70324.
@article{d2026,
author = {Zhang D and Huang QF and Li Y and Wang JG},
title = {Serum Uric Acid Changes in Relation to Nighttime Blood Pressure Dipping Status in Patients on Antihypertensive Therapy.},
journal = {Journal of clinical hypertension (Greenwich, Conn.)},
year = {2026},
doi = {10.1111/jch.70324},
note = {PMID: 42501048},
}
TY - JOUR AU - Zhang D AU - Huang QF AU - Li Y AU - Wang JG TI - Serum Uric Acid Changes in Relation to Nighttime Blood Pressure Dipping Status in Patients on Antihypertensive Therapy. T2 - Journal of clinical hypertension (Greenwich, Conn.) PY - 2026 DO - 10.1111/jch.70324 AN - PMID:42501048 ER -
We performed a post hoc exploratory secondary analysis to investigate whether baseline circadian blood pressure (BP) pattern was associated with changes in serum uric acid (SUA) during 8-week antihypertensive therapy. Of the 494 hypertensive patients who received amlodipine (5-10 mg) or nifedipine GITS (30-60 mg) for 8 weeks, 369 patients with available laboratory data and valid follow-up ambulatory BP monitoring data were included in the present analysis, including 221 dippers (nocturnal systolic BP decline ≥ 10%) and 148 non-dippers (nocturnal systolic BP decline < 10%). Analysis of covariance was used to estimate least square mean changes in SUA according to baseline dipping pattern. After 8-week antihypertensive treatment, SUA decreased significantly in dippers (-12.4 ± 3.4 µmol/L, p = 0.0004) but not in non-dippers (-3.3 ± 4.2 µmol/L, p = 0.44). In the repeated-measures analysis, SUA levels decreased significantly over time (p = 0.002), whereas no significant time-by-dipping interaction was observed (p = 0.23). Baseline BP dipping pattern may be modestly associated with short-term SUA changes during antihypertensive therapy. However, the absence of a significant time-by-dipping interaction suggests that these findings should be interpreted cautiously and require further confirmation.