Exercise-Induced ECG Abnormalities in Pediatric Pectus Excavatum: Evidence of Right Ventricular Compression Beyond the Haller Index.
K, G., A, B., S, S., RA, H., B, H., T, E., T, J., & R, P. (2026). Exercise-Induced ECG Abnormalities in Pediatric Pectus Excavatum: Evidence of Right Ventricular Compression Beyond the Haller Index.. Medical sciences (Basel, Switzerland). https://doi.org/10.3390/medsci14030379
K G, A B, S S, RA H, B H, T E, et al. Exercise-Induced ECG Abnormalities in Pediatric Pectus Excavatum: Evidence of Right Ventricular Compression Beyond the Haller Index.. Medical sciences (Basel, Switzerland). 2026; doi: 10.3390/medsci14030379
K G, A B, S S, et al. Exercise-Induced ECG Abnormalities in Pediatric Pectus Excavatum: Evidence of Right Ventricular Compression Beyond the Haller Index.[J]. Medical sciences (Basel, Switzerland). 2026. DOI: 10.3390/medsci14030379.
@article{k2026,
author = {Guerrier K and Bejnood A and Shyam S and Hyde RA and Hendrickson B and Eubanks T and Jancelewicz T and Philip R},
title = {Exercise-Induced ECG Abnormalities in Pediatric Pectus Excavatum: Evidence of Right Ventricular Compression Beyond the Haller Index.},
journal = {Medical sciences (Basel, Switzerland)},
year = {2026},
doi = {10.3390/medsci14030379},
note = {PMID: 42506348},
}
TY - JOUR AU - Guerrier K AU - Bejnood A AU - Shyam S AU - Hyde RA AU - Hendrickson B AU - Eubanks T AU - Jancelewicz T AU - Philip R TI - Exercise-Induced ECG Abnormalities in Pediatric Pectus Excavatum: Evidence of Right Ventricular Compression Beyond the Haller Index. T2 - Medical sciences (Basel, Switzerland) PY - 2026 DO - 10.3390/medsci14030379 AN - PMID:42506348 ER -
BACKGROUND: Pectus excavatum (PEX) is the most common congenital chest wall deformity and may result in cardiac compression and arrhythmias. The relationship between structural severity and exercise-induced electrocardiographic (ECG) abnormalities in pediatric patients remains unclear. METHODS: We performed a retrospective study of patients aged 10-19 years that underwent standardized preoperative evaluation for PEX between 2015 and 2021, including ECG, transthoracic echocardiography (TTE), computed tomography (CT), and cardiopulmonary exercise testing (CPET). PEX severity was assessed using the Haller index (HI), while right ventricular (RV) compression was evaluated on CT. Tricuspid valve annular size (TVAS) on TTE was used as a surrogate marker of RV compression. Exercise-induced ECG abnormalities, including premature ventricular complexes (PVCs), were analyzed and correlated with HI, RV compression, and TVAS. RESULTS: Among 124 patients (85% male; median age 15 years), 33% exhibited exercise-induced ECG abnormalities, most commonly PVCs (24% overall). PVC occurrence was not associated with Haller index severity (p = 0.35) but was significantly associated with RV compression on CT (92.6% vs. 62.1%, OR 7.64, p = 0.02). Patients with ECG abnormalities had significantly smaller TVAS compared to those without (1.98 ± 0.31 cm vs. 2.09 ± 0.33 cm, p = 0.04). Although PVCs were more frequent in patients with TVAS z-score ≤ -2.0, this did not reach statistical significance. CONCLUSIONS: Exercise-induced ventricular ectopy in pediatric PEX is associated with right ventricular compression rather than structural severity as defined by HI. Echocardiographic measures such as TVAS may serve as noninvasive markers of clinically significant compression. These findings highlight the importance of cardiac-thoracic relationships in predicting arrhythmic risk and suggest a potential for reversibility with surgical correction.