Does Venous Drainage Route Matter? Portal Versus Systemic Drainage in Isolated Intestinal Transplantation: An Analysis of the National UNOS Database.
V, V., A, B., M, M., G, S., A, T., R, M., A, N., H, S., J, G., & R, V. (2026). Does Venous Drainage Route Matter? Portal Versus Systemic Drainage in Isolated Intestinal Transplantation: An Analysis of the National UNOS Database.. Pediatric transplantation. https://doi.org/10.1111/petr.70400
V V, A B, M M, G S, A T, R M, et al. Does Venous Drainage Route Matter? Portal Versus Systemic Drainage in Isolated Intestinal Transplantation: An Analysis of the National UNOS Database.. Pediatric transplantation. 2026; doi: 10.1111/petr.70400
V V, A B, M M, et al. Does Venous Drainage Route Matter? Portal Versus Systemic Drainage in Isolated Intestinal Transplantation: An Analysis of the National UNOS Database.[J]. Pediatric transplantation. 2026. DOI: 10.1111/petr.70400.
@article{v2026,
author = {Venkatasamy V and Banker A and Morsi M and Selvaggi G and Tekin A and Miyashiro R and Nasrallah A and Sato H and Garcia J and Vianna R},
title = {Does Venous Drainage Route Matter? Portal Versus Systemic Drainage in Isolated Intestinal Transplantation: An Analysis of the National UNOS Database.},
journal = {Pediatric transplantation},
year = {2026},
doi = {10.1111/petr.70400},
note = {PMID: 42524878},
}
TY - JOUR AU - Venkatasamy V AU - Banker A AU - Morsi M AU - Selvaggi G AU - Tekin A AU - Miyashiro R AU - Nasrallah A AU - Sato H AU - Garcia J AU - Vianna R TI - Does Venous Drainage Route Matter? Portal Versus Systemic Drainage in Isolated Intestinal Transplantation: An Analysis of the National UNOS Database. T2 - Pediatric transplantation PY - 2026 DO - 10.1111/petr.70400 AN - PMID:42524878 ER -
BACKGROUND: Type of venous drainage in isolated intestinal transplantation (ITx) may influence immune responses through hepatic filtration of gut-derived antigens and affect outcomes. METHODS: We analyzed United Network for Organ Sharing data from 2013-2023 to compare portal versus systemic drainage in pediatric and adult ITx recipients. Graft and patient survival were assessed using Kaplan-Meier and Cox proportional hazards models, and acute rejection during the index admission was evaluated with multivariable logistic regression. RESULTS: Among 480 recipients (137 pediatric, 343 adult), systemic drainage in pediatric patients was associated with higher acute rejection rates (50.7% vs. 32.4%, p = 0.029), and adjusted analysis confirmed systemic drainage as an independent risk factor (OR 2.32, 95% CI 1.00-5.37, p = 0.049). No survival differences were observed between drainage types in either age group. CONCLUSION: While venous drainage type did not affect long-term graft or patient survival, portal drainage in pediatric ITx was associated with lower odds of early acute rejection, suggesting a potential immunologic benefit that warrants prospective validation.