Effects of a Fasting-mimicking Diet on MRI-assessed Cardiac Structure and Function in Participants with Type 2 Diabetes.
R, C., JJM, W., EL, v.d.B., MP, S., S, l.C., PG, v.P., H, P., & HJ, L. (2026). Effects of a Fasting-mimicking Diet on MRI-assessed Cardiac Structure and Function in Participants with Type 2 Diabetes.. Radiology. Cardiothoracic imaging. https://doi.org/10.1148/ryct.250547
R C, JJM W, EL vdB, MP S, S lC, PG vP, et al. Effects of a Fasting-mimicking Diet on MRI-assessed Cardiac Structure and Function in Participants with Type 2 Diabetes.. Radiology. Cardiothoracic imaging. 2026; doi: 10.1148/ryct.250547
R C, JJM W, EL vdB, et al. Effects of a Fasting-mimicking Diet on MRI-assessed Cardiac Structure and Function in Participants with Type 2 Diabetes.[J]. Radiology. Cardiothoracic imaging. 2026. DOI: 10.1148/ryct.250547.
@article{r2026,
author = {Chen R and Westenberg JJM and van den Burg EL and Schoonakker MP and le Cessie S and van Peet PG and Pijl H and Lamb HJ},
title = {Effects of a Fasting-mimicking Diet on MRI-assessed Cardiac Structure and Function in Participants with Type 2 Diabetes.},
journal = {Radiology. Cardiothoracic imaging},
year = {2026},
doi = {10.1148/ryct.250547},
note = {PMID: 42530457},
}
TY - JOUR AU - Chen R AU - Westenberg JJM AU - van den Burg EL AU - Schoonakker MP AU - le Cessie S AU - van Peet PG AU - Pijl H AU - Lamb HJ TI - Effects of a Fasting-mimicking Diet on MRI-assessed Cardiac Structure and Function in Participants with Type 2 Diabetes. T2 - Radiology. Cardiothoracic imaging PY - 2026 DO - 10.1148/ryct.250547 AN - PMID:42530457 ER -
Purpose To evaluate the effects of a monthly 5-day fasting-mimicking diet (FMD) for 1 year on left ventricular (LV) geometry and function in individuals with type 2 diabetes (T2D). Materials and Methods This secondary analysis of the prospective Fasting In diabetes Treatment trial (ClinicalTrials.gov identifier no. NCT03811587) included individuals with T2D randomized to monthly 5-day FMD or usual care for 12 months (November 2018-July 2020). MRI (3.0 T) was performed at baseline, 6 months, and 12 months. LV geometry and systolic function were assessed from two-dimensional cine images, and diastolic function was assessed from four-dimensional flow MRI. Intention-to-treat linear mixed models and linear regression were used to evaluate treatment effects and LV-metabolic associations. Results A total of 82 participants (mean age, 62.9 years ± 8.5 [SD]; 43 female) were included. FMD reduced LV mass at 6 months (mean difference, -5.47 g [95% CI: -9.19, -1.75]; P = .005) but not at 12 months (P = .83). End-diastolic volume remained stable in the FMD group versus controls (mean difference, 7.75 mL [95% CI: 0.19, 15.32]; P = .045). Both the early-to-late peak filling ratio (E/A) (mean difference, 0.27 [95% CI: 0.04, 0.50]; P = .02) and the mitral annular early peak velocity (Ea) (mean difference, 0.84 cm/sec [95% CI: -0.02, 1.67]; P = .04) increased at 12 months. No other treatment effects were observed (all P > .05). ∆E/A was positively associated with change in hemoglobin A1c (HbA1c) level (standardized β = 0.47, P = .01) and negatively associated with changes in high-density lipoprotein cholesterol levels (standardized β = -0.55, P = .01). Conclusion FMD positively influenced LV diastolic function by increasing E/A and Ea in participants with T2D; E/A improvements were associated with reduced HbA1c levels. Keywords: MR Imaging, Cardiac, Left Ventricle, Outcomes Analysis, Metabolic Disorders, Diet, Fasting-mimicking Diet, Left Ventricle Function, Type 2 Diabetes, Cardiac Magnetic Resonance ClinicalTrials.gov identifier number NCT03811587 Supplemental material is available for this article. © RSNA, 2026.