Hypertension is associated with an increased risk of peritoneal dialysis-associated peritonitis: a retrospective cohort study.
S, Z., H, L., Q, W., J, H., J, H., Y, L., & Y, X. (2026). Hypertension is associated with an increased risk of peritoneal dialysis-associated peritonitis: a retrospective cohort study.. Frontiers in cellular and infection microbiology. https://doi.org/10.3389/fcimb.2026.1807316
S Z, H L, Q W, J H, J H, Y L, et al. Hypertension is associated with an increased risk of peritoneal dialysis-associated peritonitis: a retrospective cohort study.. Frontiers in cellular and infection microbiology. 2026; doi: 10.3389/fcimb.2026.1807316
S Z, H L, Q W, et al. Hypertension is associated with an increased risk of peritoneal dialysis-associated peritonitis: a retrospective cohort study.[J]. Frontiers in cellular and infection microbiology. 2026. DOI: 10.3389/fcimb.2026.1807316.
@article{s2026,
author = {Zhong S and Liu H and Wang Q and Hu J and Huang J and Li Y and Xiao Y},
title = {Hypertension is associated with an increased risk of peritoneal dialysis-associated peritonitis: a retrospective cohort study.},
journal = {Frontiers in cellular and infection microbiology},
year = {2026},
doi = {10.3389/fcimb.2026.1807316},
note = {PMID: 42534804},
}
TY - JOUR AU - Zhong S AU - Liu H AU - Wang Q AU - Hu J AU - Huang J AU - Li Y AU - Xiao Y TI - Hypertension is associated with an increased risk of peritoneal dialysis-associated peritonitis: a retrospective cohort study. T2 - Frontiers in cellular and infection microbiology PY - 2026 DO - 10.3389/fcimb.2026.1807316 AN - PMID:42534804 ER -
BACKGROUND: Peritoneal dialysis-associated peritonitis (PDAP) remains a major complication of peritoneal dialysis (PD) and is a leading cause of hospitalization, technique failure, and mortality. Hypertension is highly prevalent among PD patients; however, its association with PDAP risk has not been well defined. METHODS: We conducted a retrospective cohort study including adult PD patients followed between January 1, 2007, and December 31, 2024. Clinical characteristics, laboratory parameters, dialysis-related features, and PDAP events were systematically collected. Hypertension was defined by a documented diagnosis, long-term use of antihypertensive medications, or repeated blood pressure measurements ≥140/90 mmHg at baseline. The cumulative incidence of PDAP was assessed using cumulative incidence function (CIF) curves and Gray's test. Independent associations were evaluated using Fine-Gray competing risk models and multivariable logistic regression analyses. RESULTS: Among 352 PD patients, 194 (55.1%) had hypertension. During a mean follow-up of 46.1 months, hypertensive patients exhibited a significantly higher cumulative incidence of PDAP. After multivariable adjustment, hypertension remained independently associated with a higher risk of PDAP in both Fine-Gray competing risk models (HR = 4.46, 95% CI 2.49-7.99, P < 0.001) and logistic regression analyses (OR = 4.38, 95% CI 2.11-9.08, P < 0.001). In descriptive microbiological analyses, hypertensive patients showed a higher proportion of gram-negative organisms, whereas gram-positive organisms predominated in non-hypertensive patients. CONCLUSION: Baseline hypertension was independently associated with a higher risk of PDAP in patients undergoing PD. These findings highlight the potential importance of blood pressure status in PDAP risk stratification and long-term PD management.