Systemic Comorbidities in Central Centrifugal Cicatricial Alopecia: A Systematic Review and Meta-analysis.
JL, S.C., FJ, G.G., B, U., EB, S.C., J, G.M., B, I.T., AJ, V.G.N., E, G.Y., & J, R. (2026). Systemic Comorbidities in Central Centrifugal Cicatricial Alopecia: A Systematic Review and Meta-analysis.. Acta dermato-venereologica. https://doi.org/10.2340/actadv.v106.adv-2026-0456
JL SC, FJ GG, B U, EB SC, J GM, B IT, et al. Systemic Comorbidities in Central Centrifugal Cicatricial Alopecia: A Systematic Review and Meta-analysis.. Acta dermato-venereologica. 2026; doi: 10.2340/actadv.v106.adv-2026-0456
JL SC, FJ GG, B U, et al. Systemic Comorbidities in Central Centrifugal Cicatricial Alopecia: A Systematic Review and Meta-analysis.[J]. Acta dermato-venereologica. 2026. DOI: 10.2340/actadv.v106.adv-2026-0456.
@article{jl2026,
author = {Sanz-Cabanillas JL and Gómez-García FJ and Ungar B and Sanz-Cabanillas EB and Gay-Mimbrera J and Isla-Tejera B and Vélez García-Nieto AJ and Guttman-Yassky E and Ruano J},
title = {Systemic Comorbidities in Central Centrifugal Cicatricial Alopecia: A Systematic Review and Meta-analysis.},
journal = {Acta dermato-venereologica},
year = {2026},
doi = {10.2340/actadv.v106.adv-2026-0456},
note = {PMID: 42549602},
}
TY - JOUR AU - Sanz-Cabanillas JL AU - Gómez-García FJ AU - Ungar B AU - Sanz-Cabanillas EB AU - Gay-Mimbrera J AU - Isla-Tejera B AU - Vélez García-Nieto AJ AU - Guttman-Yassky E AU - Ruano J TI - Systemic Comorbidities in Central Centrifugal Cicatricial Alopecia: A Systematic Review and Meta-analysis. T2 - Acta dermato-venereologica PY - 2026 DO - 10.2340/actadv.v106.adv-2026-0456 AN - PMID:42549602 ER -
Central centrifugal cicatricial alopecia (CCCA) is the most common scarring alopecia among women of African descent and has been increasingly associated with systemic comorbidities, particularly cardiometabolic and fibroproliferative conditions. We conducted a PRISMA 2020 compliant systematic review and random-effects meta-analysis, prospectively registered in PROSPERO (CRD420250656067), to quantify pooled prevalence estimates and case-control associations for comorbidities in CCCA. MEDLINE and Embase were searched through 18 June 2025 for observational studies reporting comorbidities in CCCA. Twenty three studies, comprising 9,103 patients with CCCA, were eligible. Hypertension (51.9%, 95% CI 33.8-69.6), dyslipidemia (58.4%, 95% CI 29.0 82.8), obesity (37.1%, 95% CI 10.8-74.2) and uterine leiomyomas (28.0%, 95% CI 8.0-64.0) were frequently reported, with substantial heterogeneity across studies. In case-control analyses, CCCA was significantly associated with dyslipidaemia (OR 4.46, 95% CI 1.09-18.25), uterine leiomyomas (OR 2.25, 95% CI 1.10-4.58) and anxiety disorders (OR 3.27, 95% CI 1.22-8.79), whereas hypertension, obesity and thyroid disease were not consistently associated. Most included studies were retrospective and predominantly U.S.-based, contributing to methodological heterogeneity. These findings suggest that CCCA may be accompanied by a substantial burden of medically recorded systemic comorbidities and support holistic, individualized clinical assessment.