Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.
Tian, X., Alireza, A., Ahmad, V., M, N.I., Shaoyong, S., Mami, I., Siqi, W., Wenbo, Z., Goncalves, S.A., Ehsan, M., Lucinda, C., Justiina, R., T, P.C.E., Xueling, L., E, S.S., F, F.J., Evelina, S., A, W.C., Elisabeth, T., . . . Harold, S. (2026). Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.. Eur Heart J. https://doi.org/10.1093/eurheartj/ehag313
Tian X, Alireza A, Ahmad V, M NI, Shaoyong S, Mami I, et al. Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.. Eur Heart J. 2026; doi: 10.1093/eurheartj/ehag313
Tian X, Alireza A, Ahmad V, et al. Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.[J]. Eur Heart J. 2026. DOI: 10.1093/eurheartj/ehag313.
@article{tian2026,
author = {Xie Tian and Ani Alireza and Vaez Ahmad and Nolte Ilja M and Su Shaoyong and Ishikuro Mami and Wang Siqi and Zhang Wenbo and Soares Ana Goncalves and Motazedi Ehsan and Calas Lucinda and Ronkainen Justiina and Pedersen Casper-Emil T and Lu Xueling and Stinson Sara E and Felix Janine F and Stankevic Evelina and Wang Carol A and Thiering Elisabeth and Fernández Dietmar and Calvo-Serra Beatriz and Stathopoulou Maria G and Fore Ruby and Kumar Ashish and Tuhkanen Johanna and Bilbao Jose Ramon and Ibarluzea Jesus and Isaacs Aaron and Fonvig Cilius Esmann and Rivadeneira Fernando and Lund Morten Asp Vonsild and Holm Louise Aas and van der Most Peter J and Riese Harriëtte and Narita Akira and Tamiya Gen and Flexeder Claudia and Wiersma Rikstje and Argoty-Pantoja Anna D and Vinding Rebecca and Hansen Tine Willum and Kümler Thomas and Estarlich Marisa and Bustamante Mariona and Yuan Wen Lun and Boland-Augé Anne and Deleuze Jean-François and Petrelis Alexandros M and Rifas-Shiman Sheryl and Kajantie Eero and Fernandez-Jimenez Nora and Santa-Marina Loreto and Arts Ilja C W and Lahti Jari and Strandberg Timo and Kull Inger and Bergström Anna and Hivert Marie-France and Bønnelykke Klaus and Kuriyama Shinichi and Beilin Lawrence J and Mori Trevor A and Hartman Catharina A and Grarup Niels and Thijs Carel and Räikkönen Katri and Melén Erik and Oken Emily and Visvikis-Siest Sophie and Gützkow Kristine B and Grazuleviciene Regina and Heude Barbara and Chatzi Leda and Vrijheid Martine and Standl Marie and Vrijkotte Tanja and Pennell Craig E and Oldehinkel Albertine J and Hansen Torben and Jaddoe Vincent W V and Holm Jens-Christian and Sebert Sylvain and Timpson Nicholas J and Obara Taku and Wang Xiaoling and Lawlor Deborah A and Corpeleijn Eva and Ahluwalia Tarunveer S and Snieder Harold},
title = {Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.},
journal = {Eur Heart J},
year = {2026},
doi = {10.1093/eurheartj/ehag313},
note = {PMID: 42036355},
}
TY - JOUR AU - Xie Tian AU - Ani Alireza AU - Vaez Ahmad AU - Nolte Ilja M AU - Su Shaoyong AU - Ishikuro Mami AU - Wang Siqi AU - Zhang Wenbo AU - Soares Ana Goncalves AU - Motazedi Ehsan AU - Calas Lucinda AU - Ronkainen Justiina AU - Pedersen Casper-Emil T AU - Lu Xueling AU - Stinson Sara E AU - Felix Janine F AU - Stankevic Evelina AU - Wang Carol A AU - Thiering Elisabeth AU - Fernández Dietmar AU - Calvo-Serra Beatriz AU - Stathopoulou Maria G AU - Fore Ruby AU - Kumar Ashish AU - Tuhkanen Johanna AU - Bilbao Jose Ramon AU - Ibarluzea Jesus AU - Isaacs Aaron AU - Fonvig Cilius Esmann AU - Rivadeneira Fernando AU - Lund Morten Asp Vonsild AU - Holm Louise Aas AU - van der Most Peter J AU - Riese Harriëtte AU - Narita Akira AU - Tamiya Gen AU - Flexeder Claudia AU - Wiersma Rikstje AU - Argoty-Pantoja Anna D AU - Vinding Rebecca AU - Hansen Tine Willum AU - Kümler Thomas AU - Estarlich Marisa AU - Bustamante Mariona AU - Yuan Wen Lun AU - Boland-Augé Anne AU - Deleuze Jean-François AU - Petrelis Alexandros M AU - Rifas-Shiman Sheryl AU - Kajantie Eero AU - Fernandez-Jimenez Nora AU - Santa-Marina Loreto AU - Arts Ilja C W AU - Lahti Jari AU - Strandberg Timo AU - Kull Inger AU - Bergström Anna AU - Hivert Marie-France AU - Bønnelykke Klaus AU - Kuriyama Shinichi AU - Beilin Lawrence J AU - Mori Trevor A AU - Hartman Catharina A AU - Grarup Niels AU - Thijs Carel AU - Räikkönen Katri AU - Melén Erik AU - Oken Emily AU - Visvikis-Siest Sophie AU - Gützkow Kristine B AU - Grazuleviciene Regina AU - Heude Barbara AU - Chatzi Leda AU - Vrijheid Martine AU - Standl Marie AU - Vrijkotte Tanja AU - Pennell Craig E AU - Oldehinkel Albertine J AU - Hansen Torben AU - Jaddoe Vincent W V AU - Holm Jens-Christian AU - Sebert Sylvain AU - Timpson Nicholas J AU - Obara Taku AU - Wang Xiaoling AU - Lawlor Deborah A AU - Corpeleijn Eva AU - Ahluwalia Tarunveer S AU - Snieder Harold TI - Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure. T2 - Eur Heart J PY - 2026 DO - 10.1093/eurheartj/ehag313 AN - PMID:42036355 ER -
To elucidate the genetic architecture of blood pressure (BP) and heart rate (HR) during early life and assess their potential relevance to adult health outcomes. The largest genome-wide association study (GWAS) meta-analyses to date of childhood systolic BP, diastolic BP, pulse pressure, and mean arterial pressure (n = 28 425) and HR (n = 22 565) were conducted in children of European ancestry aged 4-17 years. Follow-up analyses included comparisons with adult GWAS results, polygenic risk score (PRS) analyses in independent cohorts of diverse ancestries, and a phenome-wide association study in the UK Biobank. Eight genome-wide significant loci were identified for childhood BP (KIAA2013, CACNB2, PLCE1, PAX2, COL4A2, RP11-236L14.1, CFDP1, TPX2) and three loci for childhood HR (CCDC141, ACHE, MYH6); all novel in children but previously reported in adults. Childhood PRSs explained up to 1.6% of BP variance and 5.2% of HR variance among children of European ancestry. Genetic correlations between childhood and adulthood BP traits were moderate (rg = 0.4-0.7), suggesting age-specific genetic effects on BP. In the UK Biobank, higher childhood BP PRS levels were significantly associated with a broad range of adult health outcomes, particularly cardiometabolic outcomes such as hypertension, angina, myocardial infarction, and cardiovascular disease-related mortality. These findings advance the understanding of the genetic architecture of childhood BP and HR and provide compelling genetic evidence linking childhood BP to a broad spectrum of adult health outcomes-particularly cardiometabolic conditions-which may inform targeted prevention strategies from a young age.