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Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.

Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.

期刊: Eur Heart J 日期: 2026-01-01 PMID: 42036355 DOI: 10.1093/eurheartj/ehag313 浏览: 57
作者: Xie Tian, Ani Alireza, Vaez Ahmad, Nolte Ilja M, Su Shaoyong, Ishikuro Mami, Wang Siqi, Zhang Wenbo, Soares Ana Goncalves, Motazedi Ehsan, Calas Lucinda, Ronkainen Justiina, Pedersen Casper-Emil T, Lu Xueling, Stinson Sara E, Felix Janine F, Stankevic Evelina, Wang Carol A, Thiering Elisabeth, Fernández Dietmar, Calvo-Serra Beatriz, Stathopoulou Maria G, Fore Ruby, Kumar Ashish, Tuhkanen Johanna, Bilbao Jose Ramon, Ibarluzea Jesus, Isaacs Aaron, Fonvig Cilius Esmann, Rivadeneira Fernando, Lund Morten Asp Vonsild, Holm Louise Aas, van der Most Peter J, Riese Harriëtte, Narita Akira, Tamiya Gen, Flexeder Claudia, Wiersma Rikstje, Argoty-Pantoja Anna D, Vinding Rebecca, Hansen Tine Willum, Kümler Thomas, Estarlich Marisa, Bustamante Mariona, Yuan Wen Lun, Boland-Augé Anne, Deleuze Jean-François, Petrelis Alexandros M, Rifas-Shiman Sheryl, Kajantie Eero, Fernandez-Jimenez Nora, Santa-Marina Loreto, Arts Ilja C W, Lahti Jari, Strandberg Timo, Kull Inger, Bergström Anna, Hivert Marie-France, Bønnelykke Klaus, Kuriyama Shinichi, Beilin Lawrence J, Mori Trevor A, Hartman Catharina A, Grarup Niels, Thijs Carel, Räikkönen Katri, Melén Erik, Oken Emily, Visvikis-Siest Sophie, Gützkow Kristine B, Grazuleviciene Regina, Heude Barbara, Chatzi Leda, Vrijheid Martine, Standl Marie, Vrijkotte Tanja, Pennell Craig E, Oldehinkel Albertine J, Hansen Torben, Jaddoe Vincent W V, Holm Jens-Christian, Sebert Sylvain, Timpson Nicholas J, Obara Taku, Wang Xiaoling, Lawlor Deborah A, Corpeleijn Eva, Ahluwalia Tarunveer S, Snieder Harold
Tian, X., Alireza, A., Ahmad, V., M, N.I., Shaoyong, S., Mami, I., Siqi, W., Wenbo, Z., Goncalves, S.A., Ehsan, M., Lucinda, C., Justiina, R., T, P.C.E., Xueling, L., E, S.S., F, F.J., Evelina, S., A, W.C., Elisabeth, T., . . . Harold, S. (2026). Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.. Eur Heart J. https://doi.org/10.1093/eurheartj/ehag313
Tian X, Alireza A, Ahmad V, M NI, Shaoyong S, Mami I, et al. Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.. Eur Heart J. 2026; doi: 10.1093/eurheartj/ehag313
Tian X, Alireza A, Ahmad V, et al. Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.[J]. Eur Heart J. 2026. DOI: 10.1093/eurheartj/ehag313.
@article{tian2026,
  author = {Xie Tian and Ani Alireza and Vaez Ahmad and Nolte Ilja M and Su Shaoyong and Ishikuro Mami and Wang Siqi and Zhang Wenbo and Soares Ana Goncalves and Motazedi Ehsan and Calas Lucinda and Ronkainen Justiina and Pedersen Casper-Emil T and Lu Xueling and Stinson Sara E and Felix Janine F and Stankevic Evelina and Wang Carol A and Thiering Elisabeth and Fernández Dietmar and Calvo-Serra Beatriz and Stathopoulou Maria G and Fore Ruby and Kumar Ashish and Tuhkanen Johanna and Bilbao Jose Ramon and Ibarluzea Jesus and Isaacs Aaron and Fonvig Cilius Esmann and Rivadeneira Fernando and Lund Morten Asp Vonsild and Holm Louise Aas and van der Most Peter J and Riese Harriëtte and Narita Akira and Tamiya Gen and Flexeder Claudia and Wiersma Rikstje and Argoty-Pantoja Anna D and Vinding Rebecca and Hansen Tine Willum and Kümler Thomas and Estarlich Marisa and Bustamante Mariona and Yuan Wen Lun and Boland-Augé Anne and Deleuze Jean-François and Petrelis Alexandros M and Rifas-Shiman Sheryl and Kajantie Eero and Fernandez-Jimenez Nora and Santa-Marina Loreto and Arts Ilja C W and Lahti Jari and Strandberg Timo and Kull Inger and Bergström Anna and Hivert Marie-France and Bønnelykke Klaus and Kuriyama Shinichi and Beilin Lawrence J and Mori Trevor A and Hartman Catharina A and Grarup Niels and Thijs Carel and Räikkönen Katri and Melén Erik and Oken Emily and Visvikis-Siest Sophie and Gützkow Kristine B and Grazuleviciene Regina and Heude Barbara and Chatzi Leda and Vrijheid Martine and Standl Marie and Vrijkotte Tanja and Pennell Craig E and Oldehinkel Albertine J and Hansen Torben and Jaddoe Vincent W V and Holm Jens-Christian and Sebert Sylvain and Timpson Nicholas J and Obara Taku and Wang Xiaoling and Lawlor Deborah A and Corpeleijn Eva and Ahluwalia Tarunveer S and Snieder Harold},
  title = {Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.},
  journal = {Eur Heart J},
  year = {2026},
  doi = {10.1093/eurheartj/ehag313},
  note = {PMID: 42036355},
}
TY  - JOUR
AU  - Xie Tian
AU  - Ani Alireza
AU  - Vaez Ahmad
AU  - Nolte Ilja M
AU  - Su Shaoyong
AU  - Ishikuro Mami
AU  - Wang Siqi
AU  - Zhang Wenbo
AU  - Soares Ana Goncalves
AU  - Motazedi Ehsan
AU  - Calas Lucinda
AU  - Ronkainen Justiina
AU  - Pedersen Casper-Emil T
AU  - Lu Xueling
AU  - Stinson Sara E
AU  - Felix Janine F
AU  - Stankevic Evelina
AU  - Wang Carol A
AU  - Thiering Elisabeth
AU  - Fernández Dietmar
AU  - Calvo-Serra Beatriz
AU  - Stathopoulou Maria G
AU  - Fore Ruby
AU  - Kumar Ashish
AU  - Tuhkanen Johanna
AU  - Bilbao Jose Ramon
AU  - Ibarluzea Jesus
AU  - Isaacs Aaron
AU  - Fonvig Cilius Esmann
AU  - Rivadeneira Fernando
AU  - Lund Morten Asp Vonsild
AU  - Holm Louise Aas
AU  - van der Most Peter J
AU  - Riese Harriëtte
AU  - Narita Akira
AU  - Tamiya Gen
AU  - Flexeder Claudia
AU  - Wiersma Rikstje
AU  - Argoty-Pantoja Anna D
AU  - Vinding Rebecca
AU  - Hansen Tine Willum
AU  - Kümler Thomas
AU  - Estarlich Marisa
AU  - Bustamante Mariona
AU  - Yuan Wen Lun
AU  - Boland-Augé Anne
AU  - Deleuze Jean-François
AU  - Petrelis Alexandros M
AU  - Rifas-Shiman Sheryl
AU  - Kajantie Eero
AU  - Fernandez-Jimenez Nora
AU  - Santa-Marina Loreto
AU  - Arts Ilja C W
AU  - Lahti Jari
AU  - Strandberg Timo
AU  - Kull Inger
AU  - Bergström Anna
AU  - Hivert Marie-France
AU  - Bønnelykke Klaus
AU  - Kuriyama Shinichi
AU  - Beilin Lawrence J
AU  - Mori Trevor A
AU  - Hartman Catharina A
AU  - Grarup Niels
AU  - Thijs Carel
AU  - Räikkönen Katri
AU  - Melén Erik
AU  - Oken Emily
AU  - Visvikis-Siest Sophie
AU  - Gützkow Kristine B
AU  - Grazuleviciene Regina
AU  - Heude Barbara
AU  - Chatzi Leda
AU  - Vrijheid Martine
AU  - Standl Marie
AU  - Vrijkotte Tanja
AU  - Pennell Craig E
AU  - Oldehinkel Albertine J
AU  - Hansen Torben
AU  - Jaddoe Vincent W V
AU  - Holm Jens-Christian
AU  - Sebert Sylvain
AU  - Timpson Nicholas J
AU  - Obara Taku
AU  - Wang Xiaoling
AU  - Lawlor Deborah A
AU  - Corpeleijn Eva
AU  - Ahluwalia Tarunveer S
AU  - Snieder Harold
TI  - Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.
T2  - Eur Heart J
PY  - 2026
DO  - 10.1093/eurheartj/ehag313
AN  - PMID:42036355
ER  - 

摘要

To elucidate the genetic architecture of blood pressure (BP) and heart rate (HR) during early life and assess their potential relevance to adult health outcomes. The largest genome-wide association study (GWAS) meta-analyses to date of childhood systolic BP, diastolic BP, pulse pressure, and mean arterial pressure (n = 28 425) and HR (n = 22 565) were conducted in children of European ancestry aged 4-17 years. Follow-up analyses included comparisons with adult GWAS results, polygenic risk score (PRS) analyses in independent cohorts of diverse ancestries, and a phenome-wide association study in the UK Biobank. Eight genome-wide significant loci were identified for childhood BP (KIAA2013, CACNB2, PLCE1, PAX2, COL4A2, RP11-236L14.1, CFDP1, TPX2) and three loci for childhood HR (CCDC141, ACHE, MYH6); all novel in children but previously reported in adults. Childhood PRSs explained up to 1.6% of BP variance and 5.2% of HR variance among children of European ancestry. Genetic correlations between childhood and adulthood BP traits were moderate (rg = 0.4-0.7), suggesting age-specific genetic effects on BP. In the UK Biobank, higher childhood BP PRS levels were significantly associated with a broad range of adult health outcomes, particularly cardiometabolic outcomes such as hypertension, angina, myocardial infarction, and cardiovascular disease-related mortality. These findings advance the understanding of the genetic architecture of childhood BP and HR and provide compelling genetic evidence linking childhood BP to a broad spectrum of adult health outcomes-particularly cardiometabolic conditions-which may inform targeted prevention strategies from a young age.

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