DASH Diet, Dietary Nitrate, and Nitric Oxide Bioavailability: Implications for Endothelial Dysfunction and Hypertension in Older Adults.
R, Z., Y, G., X, Y., J, F., J, L., Y, W., J, W., & C, Z. (2026). DASH Diet, Dietary Nitrate, and Nitric Oxide Bioavailability: Implications for Endothelial Dysfunction and Hypertension in Older Adults.. Molecular nutrition & food research. https://doi.org/10.1002/mnfr.70569
R Z, Y G, X Y, J F, J L, Y W, et al. DASH Diet, Dietary Nitrate, and Nitric Oxide Bioavailability: Implications for Endothelial Dysfunction and Hypertension in Older Adults.. Molecular nutrition & food research. 2026; doi: 10.1002/mnfr.70569
R Z, Y G, X Y, et al. DASH Diet, Dietary Nitrate, and Nitric Oxide Bioavailability: Implications for Endothelial Dysfunction and Hypertension in Older Adults.[J]. Molecular nutrition & food research. 2026. DOI: 10.1002/mnfr.70569.
@article{r2026,
author = {Zhong R and Guo Y and You X and Fu J and Liu J and Wen Y and Wen J and Zhao C},
title = {DASH Diet, Dietary Nitrate, and Nitric Oxide Bioavailability: Implications for Endothelial Dysfunction and Hypertension in Older Adults.},
journal = {Molecular nutrition & food research},
year = {2026},
doi = {10.1002/mnfr.70569},
note = {PMID: 42563436},
}
TY - JOUR AU - Zhong R AU - Guo Y AU - You X AU - Fu J AU - Liu J AU - Wen Y AU - Wen J AU - Zhao C TI - DASH Diet, Dietary Nitrate, and Nitric Oxide Bioavailability: Implications for Endothelial Dysfunction and Hypertension in Older Adults. T2 - Molecular nutrition & food research PY - 2026 DO - 10.1002/mnfr.70569 AN - PMID:42563436 ER -
Hypertension in the elderly is closely associated with vascular aging, characterized by endothelial dysfunction (ED) and a progressive decline in nitric oxide (NO) bioavailability. Age-related dysfunction of endothelial nitric oxide synthase (eNOS), compounded by increased oxidative stress, creates a vicious cycle of oxidative-nitrosative imbalance, leading to chronic inflammation and arterial stiffness. The Dietary Approaches to Stop Hypertension (DASH) diet was developed as a primary intervention to restore NO balance by protecting endogenous pathways and supplying alternative nitrate-nitrite-NO precursors. However, its cardiovascular benefits are often diminished by age-related alterations in nitrate metabolism and the extensive use of multiple medications in the elderly. Thus, while restoring balance remains a key therapeutic goal, future clinical strategies must evolve from broad dietary recommendations to more personalized, precise nutritional approaches, considering the unique physiological and pharmacological challenges faced by older adults.