Combining partial splenic embolization with hepatic artery infusion chemotherapy in the management of chemotherapy-induced hypersplenism in patients with colorectal cancer liver metastases.
B, L., S, G., H, Z., J, G., F, K., S, L., X, Z., A, F., X, W., & G, C. (2026). Combining partial splenic embolization with hepatic artery infusion chemotherapy in the management of chemotherapy-induced hypersplenism in patients with colorectal cancer liver metastases.. Journal of cancer research and therapeutics. https://doi.org/10.4103/jcrt.jcrt_685_25
B L, S G, H Z, J G, F K, S L, et al. Combining partial splenic embolization with hepatic artery infusion chemotherapy in the management of chemotherapy-induced hypersplenism in patients with colorectal cancer liver metastases.. Journal of cancer research and therapeutics. 2026; doi: 10.4103/jcrt.jcrt_685_25
B L, S G, H Z, et al. Combining partial splenic embolization with hepatic artery infusion chemotherapy in the management of chemotherapy-induced hypersplenism in patients with colorectal cancer liver metastases.[J]. Journal of cancer research and therapeutics. 2026. DOI: 10.4103/jcrt.jcrt_685_25.
@article{b2026,
author = {Liu B and Gao S and Zheng H and Guo J and Kou F and Liu S and Zhang X and Feng A and Wang X and Cao G},
title = {Combining partial splenic embolization with hepatic artery infusion chemotherapy in the management of chemotherapy-induced hypersplenism in patients with colorectal cancer liver metastases.},
journal = {Journal of cancer research and therapeutics},
year = {2026},
doi = {10.4103/jcrt.jcrt_685_25},
note = {PMID: 42241173},
}
TY - JOUR AU - Liu B AU - Gao S AU - Zheng H AU - Guo J AU - Kou F AU - Liu S AU - Zhang X AU - Feng A AU - Wang X AU - Cao G TI - Combining partial splenic embolization with hepatic artery infusion chemotherapy in the management of chemotherapy-induced hypersplenism in patients with colorectal cancer liver metastases. T2 - Journal of cancer research and therapeutics PY - 2026 DO - 10.4103/jcrt.jcrt_685_25 AN - PMID:42241173 ER -
BACKGROUND: While partial splenic artery embolization (PSE) has been effectively employed in treating portal hypertension, cirrhosis, and idiopathic thrombocytopenia, its combination with hepatic artery infusion chemotherapy (HAIC) for the management of chemotherapy-induced hypersplenism (CIH) has not been previously explored. This retrospective study aims to provide clinical insights into this potential therapeutic approach. MATERIALS AND METHODS: We conducted a retrospective analysis involving patients with colorectal cancer liver metastases (CRLM) who received PSE in conjunction with HAIC (utilizing the FOLFOX regimen) to manage thrombocytopenia due to hypersplenism. Tumor response assessment followed the response evaluation criteria in solid tumors, while adverse reactions were categorized using the Common Terminology Criteria for Adverse Events (version 5.0). The primary objective was to attain a platelet (PLT) count of 100 × 10 9 /L, with secondary objectives encompassing evaluation of adverse events related to the combined therapy and its efficacy against liver metastases. RESULTS: From January 2018 to May 2023, 20 patients with CRLM and CIH were consecutively enrolled in this investigation, each undergoing PSE and HAIC. In total, PSE was performed 25 times. Median pre- and post-PSE PLT counts were 51 × 10 9 /L and 116 × 10 9 /L, respectively, with 80% of participants reaching the primary endpoint of a PLT count of ≥100 × 10 9 /L. Abdominal pain emerged as the most frequent postoperative complication, affecting 11 patients (44%). The objective response rate stood at 25%, while the disease-control rate was reported at 80%. The median progression-free survival was measured at 3.9 months, with a median overall survival of 13.8 months. CONCLUSION: The combination of PSE and HAIC (FOLFOX regimen) represents a safe and effective strategy for managing CIH and CRLM, demonstrating favorable outcomes in PLT count restoration and disease control.