Midlife hypertension and late-life cognition: weighting the LifeAfter90 study.
HL, C., JN, R., MM, C., CC, M., KM, G., MM, G., P, G., & RA, W. (2026). Midlife hypertension and late-life cognition: weighting the LifeAfter90 study.. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.71544
HL C, JN R, MM C, CC M, KM G, MM G, et al. Midlife hypertension and late-life cognition: weighting the LifeAfter90 study.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026; doi: 10.1002/alz.71544
HL C, JN R, MM C, et al. Midlife hypertension and late-life cognition: weighting the LifeAfter90 study.[J]. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026. DOI: 10.1002/alz.71544.
@article{hl2026,
author = {Colbeth HL and Roscoe JN and Corrada MM and Meunier CC and George KM and Glymour MM and Gilsanz P and Whitmer RA},
title = {Midlife hypertension and late-life cognition: weighting the LifeAfter90 study.},
journal = {Alzheimer's & dementia : the journal of the Alzheimer's Association},
year = {2026},
doi = {10.1002/alz.71544},
note = {PMID: 42252490},
}
TY - JOUR AU - Colbeth HL AU - Roscoe JN AU - Corrada MM AU - Meunier CC AU - George KM AU - Glymour MM AU - Gilsanz P AU - Whitmer RA TI - Midlife hypertension and late-life cognition: weighting the LifeAfter90 study. T2 - Alzheimer's & dementia : the journal of the Alzheimer's Association PY - 2026 DO - 10.1002/alz.71544 AN - PMID:42252490 ER -
INTRODUCTION: Midlife hypertension is a well-established predictor of late-life cognitive decline; however, few population-representative estimates of this association exist among oldest-old cohorts. METHODS: LifeAfter90 (LA90) is an ethnoracially diverse cohort of individuals aged 90+ linked to midlife multiphasic health check-ups (MHC). We assessed executive function, semantic memory, and verbal memory at age 90+. We used stabilized inverse probability of censoring weights and linear regression to estimate the association between midlife hypertension and cognitive function in the MHC target population. RESULTS: After weighting, LA90 participants (n = 307) were similar to the MHC population on race/ethnicity, hypertension, and education. Midlife hypertension was not associated with executive function (β = 0.03, [95% confidence interval [CI]: -0.24, 0.31]) and verbal memory (β = -0.10 [95% CI: -0.37, 0.16]). Midlife hypertension was associated with poorer semantic memory (β = -0.19 [95% CI: -0.44, 0.06]). DISCUSSION: People with midlife hypertension averaged lower semantic memory using population-representative models, suggesting that it may have sustained impact on learning and memory in those aged 90+.