Quantifying the impact of coronary-related experimental simplifications on flow features in native and neo-sinus following transcatheter aortic valve implantation.
Y, W., F, C., T, W., SV, J., T, Z., M, C., & P, W. (2026). Quantifying the impact of coronary-related experimental simplifications on flow features in native and neo-sinus following transcatheter aortic valve implantation.. Biomechanics and modeling in mechanobiology. https://doi.org/10.1007/s10237-026-02111-4
Y W, F C, T W, SV J, T Z, M C, et al. Quantifying the impact of coronary-related experimental simplifications on flow features in native and neo-sinus following transcatheter aortic valve implantation.. Biomechanics and modeling in mechanobiology. 2026; doi: 10.1007/s10237-026-02111-4
Y W, F C, T W, et al. Quantifying the impact of coronary-related experimental simplifications on flow features in native and neo-sinus following transcatheter aortic valve implantation.[J]. Biomechanics and modeling in mechanobiology. 2026. DOI: 10.1007/s10237-026-02111-4.
@article{y2026,
author = {Wei Y and Chen F and Wang T and Jansen SV and Zheng T and Chen M and Wu P},
title = {Quantifying the impact of coronary-related experimental simplifications on flow features in native and neo-sinus following transcatheter aortic valve implantation.},
journal = {Biomechanics and modeling in mechanobiology},
year = {2026},
doi = {10.1007/s10237-026-02111-4},
note = {PMID: 42567986},
}
TY - JOUR AU - Wei Y AU - Chen F AU - Wang T AU - Jansen SV AU - Zheng T AU - Chen M AU - Wu P TI - Quantifying the impact of coronary-related experimental simplifications on flow features in native and neo-sinus following transcatheter aortic valve implantation. T2 - Biomechanics and modeling in mechanobiology PY - 2026 DO - 10.1007/s10237-026-02111-4 AN - PMID:42567986 ER -
Existing in vitro and numerical studies lack consensus regarding whether and how coronary arteries should be incorporated. This study aims to systematically investigate the effects of coronary artery outlets on the hemodynamic environment within the native sinus and neo-sinus after transcatheter aortic valve implantation (TAVI). Three idealized aortic root models (without coronaries, single coronary, and bilateral coronaries) were fabricated. A VENUS self-expanding valve was implanted at five depths (0 mm, ± 5 mm and ± 10 mm). A pulsatile in vitro flow platform combined with particle image velocimetry (PIV) was applied to quantify velocity fields, vorticity, and particle washout. Correlations between implantation depth and hemodynamic parameters were further assessed. In control models, mean native sinus velocity without coronaries was 0.58 ± 0.49 cm/s and decreased further after TAVI. Introducing a single coronary increased mean velocity to 1.34 ± 0.95 cm/s and generated high-velocity jets (> 10 cm/s) near the ostium; bilateral coronaries produced comparable effects. Vorticity decreased in all post-TAVI configurations. Particle washout analysis demonstrated pronounced stasis without coronary flow but markedly improved clearance when coronary inflow was present. With coronary flow, particle washout was markedly enhanced compared with the no-coronary condition, but did not vary monotonically with implantation depth; instead, it appeared to be governed by the combined effects of local flow environment. Under the present conditions, coronary flow substantially increased velocity magnitude, vorticity, and particle washout within the corresponding native sinus and neo-sinus after self-expanding valve implantation. Neglecting coronary outlets may lead to a substantial underestimation of sinus flow velocity and washout. However, when evaluating the hemodynamics of an individual coronary sinus, inclusion of its corresponding coronary artery alone is likely to be sufficient to capture the essential flow characteristics.