Spatiotemporal Strategies for Lipid-Based Nanocarriers in Stroke.
M, X., N, Z., Q, M., L, Z., Z, Y., X, F., & C, B. (2026). Spatiotemporal Strategies for Lipid-Based Nanocarriers in Stroke.. ACS biomaterials science & engineering. https://doi.org/10.1021/acsbiomaterials.6c00712
M X, N Z, Q M, L Z, Z Y, X F, et al. Spatiotemporal Strategies for Lipid-Based Nanocarriers in Stroke.. ACS biomaterials science & engineering. 2026; doi: 10.1021/acsbiomaterials.6c00712
M X, N Z, Q M, et al. Spatiotemporal Strategies for Lipid-Based Nanocarriers in Stroke.[J]. ACS biomaterials science & engineering. 2026. DOI: 10.1021/acsbiomaterials.6c00712.
@article{m2026,
author = {Xiao M and Zhang N and Meng Q and Zhou L and Yang Z and Feng X and Bao C},
title = {Spatiotemporal Strategies for Lipid-Based Nanocarriers in Stroke.},
journal = {ACS biomaterials science & engineering},
year = {2026},
doi = {10.1021/acsbiomaterials.6c00712},
note = {PMID: 42573488},
}
TY - JOUR AU - Xiao M AU - Zhang N AU - Meng Q AU - Zhou L AU - Yang Z AU - Feng X AU - Bao C TI - Spatiotemporal Strategies for Lipid-Based Nanocarriers in Stroke. T2 - ACS biomaterials science & engineering PY - 2026 DO - 10.1021/acsbiomaterials.6c00712 AN - PMID:42573488 ER -
Stroke remains a leading global health problem, and effective neuroprotective and regenerative therapies are still limited. Although acute-phase reperfusion strategies have advanced, their narrow therapeutic windows and the risk of reperfusion injury highlight the urgent need for broader neuroprotective and regenerative approaches. Here, we review lipid-based nanocarriers as a drug delivery platform, with a particular focus on spatiotemporal drug delivery across distinct stroke phases (acute, subacute, and recovery). To date, no dedicated review has comprehensively summarized the spatiotemporal applications of lipid-based nanocarriers in stroke therapy. We discuss their potential for blood-brain barrier (BBB) penetration, inflammation modulation, and neural regeneration. Despite these promising opportunities, substantial challenges remain, including standardized formulation and barriers to clinical translation. This review offers theoretical and practical guidance for future translational efforts, emphasizing chemical design of lipid-based carriers and its role in optimizing therapeutic efficacy.