Re: Aerobic Exercise Plus Hypocaloric Diet on Serum Leptin Concentrations in Adults With Primary Hypertension and Overweight/Obesity: Results From the EXERDIET-HTA Trial.
MMUD, M. (2026). Re: Aerobic Exercise Plus Hypocaloric Diet on Serum Leptin Concentrations in Adults With Primary Hypertension and Overweight/Obesity: Results From the EXERDIET-HTA Trial.. Clinical obesity. https://doi.org/10.1111/cob.70094
MMUD M. Re: Aerobic Exercise Plus Hypocaloric Diet on Serum Leptin Concentrations in Adults With Primary Hypertension and Overweight/Obesity: Results From the EXERDIET-HTA Trial.. Clinical obesity. 2026; doi: 10.1111/cob.70094
MMUD M. Re: Aerobic Exercise Plus Hypocaloric Diet on Serum Leptin Concentrations in Adults With Primary Hypertension and Overweight/Obesity: Results From the EXERDIET-HTA Trial.[J]. Clinical obesity. 2026. DOI: 10.1111/cob.70094.
@article{mmud2026,
author = {Malik MMUD},
title = {Re: Aerobic Exercise Plus Hypocaloric Diet on Serum Leptin Concentrations in Adults With Primary Hypertension and Overweight/Obesity: Results From the EXERDIET-HTA Trial.},
journal = {Clinical obesity},
year = {2026},
doi = {10.1111/cob.70094},
note = {PMID: 42586612},
}
TY - JOUR AU - Malik MMUD TI - Re: Aerobic Exercise Plus Hypocaloric Diet on Serum Leptin Concentrations in Adults With Primary Hypertension and Overweight/Obesity: Results From the EXERDIET-HTA Trial. T2 - Clinical obesity PY - 2026 DO - 10.1111/cob.70094 AN - PMID:42586612 ER -
This correspondence addresses the EXERDIET-HTA substudy by Aparicio and colleagues, which concludes that 16 weeks of aerobic exercise plus a hypocaloric DASH diet reduced serum leptin more than diet with activity counselling in hypertensive adults with overweight or obesity. Five concerns are raised: inference from within-group p values despite a non-significant time × group interaction; pooling of three sub-threshold exercise protocols; mislabelling of an active comparator as 'attention control'; sevenfold attrition asymmetry analysed by complete-case rather than intention-to-treat methods; and effectively complete reversion of leptin at 6 months. A disaggregated, ITT re-analysis would yield more conservative but more defensible conclusions.