Left Atrial Strain Prediction of New-Onset Atrial Fibrillation in Apical Hypertrophic Cardiomyopathy with Cardiac MRI.
Y, S., M, H., T, Z., X, W., Q, F., Z, F., & L, G. (2026). Left Atrial Strain Prediction of New-Onset Atrial Fibrillation in Apical Hypertrophic Cardiomyopathy with Cardiac MRI.. Radiology. Cardiothoracic imaging. https://doi.org/10.1148/ryct.250266
Y S, M H, T Z, X W, Q F, Z F, et al. Left Atrial Strain Prediction of New-Onset Atrial Fibrillation in Apical Hypertrophic Cardiomyopathy with Cardiac MRI.. Radiology. Cardiothoracic imaging. 2026; doi: 10.1148/ryct.250266
Y S, M H, T Z, et al. Left Atrial Strain Prediction of New-Onset Atrial Fibrillation in Apical Hypertrophic Cardiomyopathy with Cardiac MRI.[J]. Radiology. Cardiothoracic imaging. 2026. DOI: 10.1148/ryct.250266.
@article{y2026,
author = {Song Y and Hu M and Zheng T and Wang X and Fang Q and Feng Z and Gong L},
title = {Left Atrial Strain Prediction of New-Onset Atrial Fibrillation in Apical Hypertrophic Cardiomyopathy with Cardiac MRI.},
journal = {Radiology. Cardiothoracic imaging},
year = {2026},
doi = {10.1148/ryct.250266},
note = {PMID: 42593264},
}
TY - JOUR AU - Song Y AU - Hu M AU - Zheng T AU - Wang X AU - Fang Q AU - Feng Z AU - Gong L TI - Left Atrial Strain Prediction of New-Onset Atrial Fibrillation in Apical Hypertrophic Cardiomyopathy with Cardiac MRI. T2 - Radiology. Cardiothoracic imaging PY - 2026 DO - 10.1148/ryct.250266 AN - PMID:42593264 ER -
Purpose To evaluate the predictive value of cardiac MRI-derived left atrial strain (LAS) for new-onset atrial fibrillation (AF) in apical hypertrophic cardiomyopathy (AHCM). Materials and Methods This retrospective study included patients with AHCM with no prior history of AF who underwent 3.0-T cardiac MRI between May 2016 and December 2023. LAS parameters-reservoir strain (εs), conduit strain (εe), and booster pump strain (εa)-and minimum left atrial volume index (LAVImin) were measured. The clinical end point was new-onset AF as confirmed with electrocardiography, Holter monitoring, or implantable cardiac devices. Cox proportional hazards models and time-dependent receiver operating characteristic (ROC) analyses were performed to evaluate associations and discriminatory performance for new-onset AF. Results A total of 156 patients (mean age, 51.0 years ± 11.5 [SD]; 113 male) were included. During a median follow-up of 33 months, AF occurred in 21 patients. In multivariable Cox models adjusted for age, body mass index, and LAVImin, LAS parameters were independently associated with incident AF (εs: hazard ratio [HR], 0.79 [95% CI: 0.69, 0.90], P < .001; εa: HR, 0.65 [95% CI: 0.50, 0.83], P < .001; and εe: HR, 0.79 [95% CI: 0.65, 0.95], P = .01). In the nested Cox models, adding LAS to a baseline clinical-volumetric model improved model fit and discrimination, with the χ2 value improving from 36.22 to 54.90 and the concordance index value improving from 0.846 to 0.930 (P < .001 for both). The LAVImin provided complementary prognostic information, with its contribution varying across strain-specific models. Time-dependent ROC analyses demonstrated that LAS identified the development of AF well across prespecified time horizons. Conclusion Cardiac MRI-derived LAS was independently associated with new-onset AF in AHCM and provided incremental prognostic value beyond routine clinical and left atrial volumetric measures. Keywords: Apical Hypertrophic Cardiomyopathy, Atrial Fibrillation, Cardiac MRI, Left Atrial Strain, Heart, Cardiomyopathies, MR Imaging Supplemental material is available for this article. © RSNA, 2026.