A cross-organ single-cell analysis of hypertension.
Q, Q., Y, L., H, X., R, P., J, L., L, H., P, L., B, T., V, K., & J, H. (2026). A cross-organ single-cell analysis of hypertension.. Science (New York, N.Y.). https://doi.org/10.1126/science.aea6187
Q Q, Y L, H X, R P, J L, L H, et al. A cross-organ single-cell analysis of hypertension.. Science (New York, N.Y.). 2026; doi: 10.1126/science.aea6187
Q Q, Y L, H X, et al. A cross-organ single-cell analysis of hypertension.[J]. Science (New York, N.Y.). 2026. DOI: 10.1126/science.aea6187.
@article{q2026,
author = {Qiu Q and Liu Y and Xue H and Pandey R and Liu J and He L and Liu P and Therani B and Kumar V and Huang J},
title = {A cross-organ single-cell analysis of hypertension.},
journal = {Science (New York, N.Y.)},
year = {2026},
doi = {10.1126/science.aea6187},
note = {PMID: 42594205},
}
TY - JOUR AU - Qiu Q AU - Liu Y AU - Xue H AU - Pandey R AU - Liu J AU - He L AU - Liu P AU - Therani B AU - Kumar V AU - Huang J TI - A cross-organ single-cell analysis of hypertension. T2 - Science (New York, N.Y.) PY - 2026 DO - 10.1126/science.aea6187 AN - PMID:42594205 ER -
Hypertension is a leading cause of disease burden and mortality. Here, we present a single-cell analysis of hypertension and end-organ damage across six organs and tissues in angiotensin II-treated mice, Dahl salt-sensitive rats, and spontaneously hypertensive rats. We identified gene programs associated with blood pressure and renal injury, including a conserved vascular smooth muscle cell program and cross-segment renal tubular programs, along with tissue-specialized endothelial adaptations and coordinated changes across cell types in select organs. Integration with human genomic data revealed model-specific and shared cell type-trait links. We prioritized a noncoding variant (rs28451064) and used genome editing to demonstrate its in vivo effect on blood pressure and allele-specific regulation of local genes. Our study provides a multimodel, cross-organ cellular resource for hypertension research.