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Blood pressure control after solid organ transplantation: opportunities for optimizing care.

Blood pressure control after solid organ transplantation: opportunities for optimizing care.

期刊: Transplant international : official journal of the European Society for Organ Transplantation 日期: 2026-01-01 PMID: 42597532 DOI: 10.3389/ti.2026.16565 浏览: 7
作者: Posthumus AM, Knobbe TJ, Kremer D, Eisenga MF, Sanders JSF, Berger SP, Smit C, Klont F, Gan CT, Verschuuren EAM
AM, P., TJ, K., D, K., MF, E., JSF, S., SP, B., C, S., F, K., CT, G., & EAM, V. (2026). Blood pressure control after solid organ transplantation: opportunities for optimizing care.. Transplant international : official journal of the European Society for Organ Transplantation. https://doi.org/10.3389/ti.2026.16565
AM P, TJ K, D K, MF E, JSF S, SP B, et al. Blood pressure control after solid organ transplantation: opportunities for optimizing care.. Transplant international : official journal of the European Society for Organ Transplantation. 2026; doi: 10.3389/ti.2026.16565
AM P, TJ K, D K, et al. Blood pressure control after solid organ transplantation: opportunities for optimizing care.[J]. Transplant international : official journal of the European Society for Organ Transplantation. 2026. DOI: 10.3389/ti.2026.16565.
@article{am2026,
  author = {Posthumus AM and Knobbe TJ and Kremer D and Eisenga MF and Sanders JSF and Berger SP and Smit C and Klont F and Gan CT and Verschuuren EAM},
  title = {Blood pressure control after solid organ transplantation: opportunities for optimizing care.},
  journal = {Transplant international : official journal of the European Society for Organ Transplantation},
  year = {2026},
  doi = {10.3389/ti.2026.16565},
  note = {PMID: 42597532},
}
TY  - JOUR
AU  - Posthumus AM
AU  - Knobbe TJ
AU  - Kremer D
AU  - Eisenga MF
AU  - Sanders JSF
AU  - Berger SP
AU  - Smit C
AU  - Klont F
AU  - Gan CT
AU  - Verschuuren EAM
TI  - Blood pressure control after solid organ transplantation: opportunities for optimizing care.
T2  - Transplant international : official journal of the European Society for Organ Transplantation
PY  - 2026
DO  - 10.3389/ti.2026.16565
AN  - PMID:42597532
ER  - 

摘要

Hypertension affects 50%-90% of solid organ transplant recipients (SOTR) and is a major driver of cardiovascular disease. Nevertheless, hypertension control has received little attention in this population. We assessed blood pressure control 1 year after heart, liver, lung or kidney transplantation using cross-sectional data from 1112 SOTR (39% female, mean age 57 ± 13 years) from the TransplantLines biobank and cohort study. Suboptimal control was defined as systolic blood pressure >130 mmHg or diastolic blood pressure >80 mmHg. Overall, 997 (90%) SOTR had hypertension. Suboptimal control occurred in 721 (72%), including 146 (20%) who received no antihypertensive treatment despite elevated blood pressure. Rates of suboptimal control were consistently high across organ types (71%-84%). Older age (OR = 1.03; 95%CI1.01-1.04), diabetes (OR = 1.99; 95%CI1.18-3.36), and higher cholesterol (OR = 1.23; 95%CI1.01-1.51) were independently associated with suboptimal control. Among treated SOTR, recipients were older (OR = 1.03; 95%CI1.01-1.05), more often male (OR = 1.55; 95%CI1.03-2.34), and had more prior cardiovascular events (OR = 2.06; 95%CI1.14-3.95). In sensitivity analyses using alternative blood pressure thresholds, suboptimal control remained common, affecting 40% of hypertensive SOTR using a ≤140/90 mmHg threshold. In conclusion, nearly three out of four hypertensive SOTR have suboptimal blood pressure control at 1 year after transplantation with a ≤130/80 mmHg threshold, highlighting a substantial care gap in post-transplant management.

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