Vascular dynamics in diabetic retinopathy: A systematic review and meta-analysis of ophthalmic Doppler indices in diabetic and non-diabetic populations.
M, H., TD, A., W, S., EP, P., Muthmainah, W, P., & S, I. (2026). Vascular dynamics in diabetic retinopathy: A systematic review and meta-analysis of ophthalmic Doppler indices in diabetic and non-diabetic populations.. Diabetes & vascular disease research. https://doi.org/10.1177/14791641261476327
M H, TD A, W S, EP P, Muthmainah, W P, et al. Vascular dynamics in diabetic retinopathy: A systematic review and meta-analysis of ophthalmic Doppler indices in diabetic and non-diabetic populations.. Diabetes & vascular disease research. 2026; doi: 10.1177/14791641261476327
M H, TD A, W S, et al. Vascular dynamics in diabetic retinopathy: A systematic review and meta-analysis of ophthalmic Doppler indices in diabetic and non-diabetic populations.[J]. Diabetes & vascular disease research. 2026. DOI: 10.1177/14791641261476327.
@article{m2026,
author = {Hanafi M and Ardyanto TD and Soewondo W and Pamungkasari EP and Muthmainah and Putranto W and Indrakila S},
title = {Vascular dynamics in diabetic retinopathy: A systematic review and meta-analysis of ophthalmic Doppler indices in diabetic and non-diabetic populations.},
journal = {Diabetes & vascular disease research},
year = {2026},
doi = {10.1177/14791641261476327},
note = {PMID: 42610439},
}
TY - JOUR AU - Hanafi M AU - Ardyanto TD AU - Soewondo W AU - Pamungkasari EP AU - Muthmainah AU - Putranto W AU - Indrakila S TI - Vascular dynamics in diabetic retinopathy: A systematic review and meta-analysis of ophthalmic Doppler indices in diabetic and non-diabetic populations. T2 - Diabetes & vascular disease research PY - 2026 DO - 10.1177/14791641261476327 AN - PMID:42610439 ER -
BackgroundOphthalmic Doppler ultrasonography is a non-invasive technique for evaluating hemodynamic changes in diabetic patients. This meta-analysis assessed ophthalmic Doppler indices in diabetic patients with and without retinopathy compared to non-diabetic controls.MethodsWe searched Scopus, PubMed, ScienceDirect, and SpringerLink for studies investigating Doppler ultrasound parameters in diabetic retinopathy (DR). Pooled mean differences with 95% confidence intervals were estimated using random-effects models for peak systolic velocity (PSV), end-diastolic velocity (EDV), resistive index (RI), and pulsatility index (PI). Study quality was assessed using QUADAS-2 and QUADAS-C.ResultsFourteen studies (1,217 patients) were included. People with diabetes without retinopathy showed significantly elevated RI (MD 0.08, P=0.004) and PI (MD 0.30, P<0.0001) in the ophthalmic artery versus controls. The central retinal artery showed marked reductions in PSV and EDV (P<0.00001) and increased RI (P=0.001) in established DR. RI was also elevated in the posterior ciliary artery across all diabetic stages. Diagnostic accuracy analyses yielded pooled RI sensitivity of 0.73-1.00 and PI sensitivity of 0.79-1.00.ConclusionOphthalmic artery Doppler indices, particularly RI and PI, were associated with DR severity that may represent possible additional markers of microvascular dysfunction. However, these findings require confirmation in well-designed prospective studies before RI and PI can be considered established early markers.