Interaction between genistein and the endothelial activation and stress index in relation to estimated 10-year atherosclerotic cardiovascular disease risk classification.
X, G., Y, L., S, M., & Y, Y. (2026). Interaction between genistein and the endothelial activation and stress index in relation to estimated 10-year atherosclerotic cardiovascular disease risk classification.. PloS one. https://doi.org/10.1371/journal.pone.0356477
X G, Y L, S M, Y Y. Interaction between genistein and the endothelial activation and stress index in relation to estimated 10-year atherosclerotic cardiovascular disease risk classification.. PloS one. 2026; doi: 10.1371/journal.pone.0356477
X G, Y L, S M, et al. Interaction between genistein and the endothelial activation and stress index in relation to estimated 10-year atherosclerotic cardiovascular disease risk classification.[J]. PloS one. 2026. DOI: 10.1371/journal.pone.0356477.
@article{x2026,
author = {Guo X and Lin Y and Mi S and Yin Y},
title = {Interaction between genistein and the endothelial activation and stress index in relation to estimated 10-year atherosclerotic cardiovascular disease risk classification.},
journal = {PloS one},
year = {2026},
doi = {10.1371/journal.pone.0356477},
note = {PMID: 42616739},
}
TY - JOUR AU - Guo X AU - Lin Y AU - Mi S AU - Yin Y TI - Interaction between genistein and the endothelial activation and stress index in relation to estimated 10-year atherosclerotic cardiovascular disease risk classification. T2 - PloS one PY - 2026 DO - 10.1371/journal.pone.0356477 AN - PMID:42616739 ER -
BACKGROUND: The Endothelial Activation and Stress Index (EASIX) has been proposed as a marker of endothelial stress and may be associated with atherosclerotic cardiovascular disease (ASCVD) risk. Whether urinary genistein modifies this association remains unclear. METHODS: Multivariable logistic regression examined the association between EASIX and estimated 10-year ASCVD risk classification. Effect modification by urinary genistein (<54.105 vs. ≥ 54.105 μg/g) was assessed using interaction terms and stratified analyses. Restricted cubic splines (RCS) evaluated dose-response relationships. RESULTS: In the fully adjusted model, higher EASIX was independently associated with increased ASCVD risk (OR per unit increase = 1.407; 95% CI: 1.208-1.640; P < 0.001). A significant multiplicative interaction between EASIX and genistein was observed (OR = 1.66; 95% CI: 1.17-2.35; P = 0.005). Stratified analysis showed that this adverse association was slightly attenuated in the higher genistein group (OR = 1.360; 95% CI: 1.066-1.736; P = 0.015) compared to the lower group (OR = 1.397; 95% CI: 1.202-1.624; P < 0.001). RCS analyses showed a non-linear S-shaped association in the lower-genistein group (P nonlinear = 0.020), whereas a predominantly linear relationship was observed in the higher-genistein group (P nonlinear = 0.108). CONCLUSIONS: Higher EASIX was associated with elevated estimated 10-year ASCVD risk classification, and this association differed across urinary genistein strata. These findings should be interpreted as hypothesis-generating.