Long-term outcomes of venous graft preservation in a rat autologous transplant model.
MJ, S., A, M., G, K., N, V., BC, D., T, S., A, E.E., H, B., I, K., & AF, J. (2026). Long-term outcomes of venous graft preservation in a rat autologous transplant model.. Scientific reports. https://doi.org/10.1038/s41598-026-55596-5
MJ S, A M, G K, N V, BC D, T S, et al. Long-term outcomes of venous graft preservation in a rat autologous transplant model.. Scientific reports. 2026; doi: 10.1038/s41598-026-55596-5
MJ S, A M, G K, et al. Long-term outcomes of venous graft preservation in a rat autologous transplant model.[J]. Scientific reports. 2026. DOI: 10.1038/s41598-026-55596-5.
@article{mj2026,
author = {Santander MJ and Mardus A and Kensah G and Voigt N and Danner BC and Stojanovic T and El-Essawi A and Baraki H and Kutschka I and Jebran AF},
title = {Long-term outcomes of venous graft preservation in a rat autologous transplant model.},
journal = {Scientific reports},
year = {2026},
doi = {10.1038/s41598-026-55596-5},
note = {PMID: 42243381},
}
TY - JOUR AU - Santander MJ AU - Mardus A AU - Kensah G AU - Voigt N AU - Danner BC AU - Stojanovic T AU - El-Essawi A AU - Baraki H AU - Kutschka I AU - Jebran AF TI - Long-term outcomes of venous graft preservation in a rat autologous transplant model. T2 - Scientific reports PY - 2026 DO - 10.1038/s41598-026-55596-5 AN - PMID:42243381 ER -
Venous grafts remain the most used conduits in coronary artery bypass grafting (CABG) but are highly susceptible to early failure due to ischemia-reperfusion injury, intimal hyperplasia, and accelerated atherosclerosis. Specialized preservation solutions such as DuraGraft and TiProtec aim to protect endothelial integrity during intraoperative storage; however, their long-term effects on venous graft adaptation remain unclear. In this study, saline, DuraGraft, and TiProtec were compared in a rat model of arterialized autologous jugular vein interposition grafting. Male Wistar rats were assigned to one of the three storage solutions or a Sham group with immediate implantation. Jugular veins were harvested, preserved for 2 h, and implanted into the infrarenal abdominal aorta using end-to-end microsurgical anastomoses. After 16 weeks, all grafts remained patent and exhibited pronounced arterial remodeling, including dilation, wall thickening, intimal hyperplasia, and loss of endothelium-dependent relaxation, while endothelium-independent relaxation was preserved. Although TiProtec-treated grafts showed slightly enhanced relaxation compared with saline-treated grafts, no preservation solution demonstrated a significant functional or structural advantage at 16 weeks. These findings suggest that long-term arterial loading is the dominant determinant of venous graft remodeling.